{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Efstathiou C"],"pubmed_abstract":["Human respiratory viruses are the most prevalent cause of disease in humans, with the highly infectious RSV being the leading cause of infant bronchiolitis and viral pneumonia. Responses to type I IFNs are the primary defense against viral infection. However, RSV proteins have been shown to antagonize type I IFN-mediated antiviral innate immunity, specifically dampening intracellular IFN signaling. Respiratory epithelial cells are the main target for RSV infection. In this study, we found RSV-NS1 interfered with the IFN-α JAK/STAT signaling pathway of epithelial cells. RSV-NS1 expression significantly enhanced IFN-α-mediated phosphorylation of STAT1, but not pSTAT2; and neither STAT1 nor STAT2 total protein levels were affected by RSV-NS1. However, expression of RSV-NS1 significantly reduc"],"journal":["Frontiers in immunology"],"pagination":["1395809"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11208467"],"repository":["biostudies-literature"],"pubmed_title":["Respiratory syncytial virus NS1 inhibits anti-viral Interferon-α-induced JAK/STAT signaling, by limiting the nuclear translocation of STAT1."],"pmcid":["PMC11208467"],"pubmed_authors":["Kandwal S","Efstathiou C","Zhang Y","Stevenson NJ","Molloy EJ","Fayne D"],"additional_accession":[]},"is_claimable":false,"name":"Respiratory syncytial virus NS1 inhibits anti-viral Interferon-α-induced JAK/STAT signaling, by limiting the nuclear translocation of STAT1.","description":"Human respiratory viruses are the most prevalent cause of disease in humans, with the highly infectious RSV being the leading cause of infant bronchiolitis and viral pneumonia. Responses to type I IFNs are the primary defense against viral infection. However, RSV proteins have been shown to antagonize type I IFN-mediated antiviral innate immunity, specifically dampening intracellular IFN signaling. Respiratory epithelial cells are the main target for RSV infection. In this study, we found RSV-NS1 interfered with the IFN-α JAK/STAT signaling pathway of epithelial cells. RSV-NS1 expression significantly enhanced IFN-α-mediated phosphorylation of STAT1, but not pSTAT2; and neither STAT1 nor STAT2 total protein levels were affected by RSV-NS1. However, expression of RSV-NS1 significantly reduc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T21:25:39.636Z","creation":"2026-05-22T03:08:12.729Z"},"accession":"S-EPMC11208467","cross_references":{"pubmed":["38938568"],"doi":["10.3389/fimmu.2024.1395809"]}}