{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gelineau A"],"funding":["Agence Nationale de la Recherche","Fondation de France","Agence Nationale de la Recherche (French National Research Agency)"],"pagination":["5413"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11208547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Diet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (HFD) in which lipids are enriched at the expense of dietary fibers. Such nutritional challenge alters glucose homeostasis as well as intestinal immunity. Here, we observed that short-term HFD induced dysbiosis, glucose intolerance and decreased intestinal RORγt<sup>+</sup> CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells. However, supplementation of HFD-fed male mice with the fermentable dietary fiber fructooligosaccharides (FOS) was sufficient to maintain RORγt<sup>+</sup> CD4 T cell subsets and microbial species known to induce them, alongside havi"],"journal":["Nature communications"],"pubmed_title":["Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells."],"pmcid":["PMC11208547"],"funding_grant_id":["ANR-17-CE14-0023","ANR-21-CE14-0023","ANR-17-CE14-0009","00056835"],"pubmed_authors":["Baba I","Huby T","Clement K","Rouault C","Marcelin G","Ouhachi M","Yvan-Charvet L","Tussiwand R","Gautier EL","Manuel R","Gelineau A","Dussaud S","Voland L"],"additional_accession":[]},"is_claimable":false,"name":"Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells.","description":"Diet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (HFD) in which lipids are enriched at the expense of dietary fibers. Such nutritional challenge alters glucose homeostasis as well as intestinal immunity. Here, we observed that short-term HFD induced dysbiosis, glucose intolerance and decreased intestinal RORγt<sup>+</sup> CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells. However, supplementation of HFD-fed male mice with the fermentable dietary fiber fructooligosaccharides (FOS) was sufficient to maintain RORγt<sup>+</sup> CD4 T cell subsets and microbial species known to induce them, alongside havi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-21T20:22:04.927Z","creation":"2025-04-05T17:58:29.326Z"},"accession":"S-EPMC11208547","cross_references":{"pubmed":["38926424"],"doi":["10.1038/s41467-024-49820-x"]}}