{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang C"],"funding":["U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)","NIDDK NIH HHS","NIA NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Cancer Institute","NCI NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","U.S. Department of Health &amp; Human Services | National Institutes of Health","NIH HHS","NIGMS NIH HHS"],"pagination":["5410"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11208586"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m<sup>6</sup>A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent manner by driving changes in high-order chromatin structure. However, how these functions of the methyltransferase complex are coordinated remains unknown. Here we show that the methyltransferase complex coordinates its enzymatic activity-dependent and independent functions to regulate cellular senescence, a state of stable cell growth arrest. Specifically, METTL3-mediated chromatin loops induce Hexokinase 2 expression through the three-dimensional chromatin organization during senescence. Elevated Hexokinase 2 expression subsequently promotes liquid-liquid phase separation,"],"journal":["Nature communications"],"pubmed_title":["METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence."],"pmcid":["PMC11208586"],"funding_grant_id":["R01 CA160331","OT2 OD030544","U2C DK119886","P30 CA010815","R00 AG065500","R01CA160331","R01 CA276569","P30 CA030199","P01 AG031862","R01CA276569","P30 CA016672","P01AG031862","R35 GM153277","R01 GM129069"],"pubmed_authors":["Havas A","Wang C","Adams PD","Tian B","Hao X","Gardini A","Goldman A","Kossenkov AV","Zhang R","Zhang Q","Nie H","Wang L","Liao L","Hill C","Tanizawa H","Noma KI","Lei X","Qi Y","Berger SL"],"additional_accession":[]},"is_claimable":false,"name":"METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.","description":"METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m<sup>6</sup>A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent manner by driving changes in high-order chromatin structure. However, how these functions of the methyltransferase complex are coordinated remains unknown. Here we show that the methyltransferase complex coordinates its enzymatic activity-dependent and independent functions to regulate cellular senescence, a state of stable cell growth arrest. Specifically, METTL3-mediated chromatin loops induce Hexokinase 2 expression through the three-dimensional chromatin organization during senescence. Elevated Hexokinase 2 expression subsequently promotes liquid-liquid phase separation,","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-01T23:38:19.305Z","creation":"2025-04-04T21:22:28.799Z"},"accession":"S-EPMC11208586","cross_references":{"pubmed":["38926365"],"doi":["10.1038/s41467-024-49745-5"]}}