biostudies-literatureOsako HJoint/Research Center on Tropical Disease, Institute of Tropical Medicine, Nagasaki UniversityJapan Society for Promotion of SciencesJapan Agency of Medical Research and DevelopmentJapan Agency for Medical Research and DevelopmentJapan Society for the Promotion of Science874https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209305biostudies-literatureUnknown16(6)Severe fever with thrombocytopenia syndrome (SFTS) is a potentially fatal tick-borne zoonosis caused by SFTS virus (SFTSV). In addition to tick bites, animal-to-human transmission of SFTSV has been reported, but little is known about feline SFTSV infection. In this study, we analyzed data on 187 cats with suspected SFTS to identify biomarkers for SFTS diagnosis and clinical outcome. Body weight, red and white blood cell and platelet counts, and serum aspartate aminotransferase and total bilirubin levels were useful for SFTS diagnosis, whereas alanine aminotransferase, aspartate aminotransferase and serum SFTSV RNA levels were associated with clinical outcome. We developed a scoring model to predict SFTSV infection. In addition, we performed a phylogenetic analysis to reveal the relationshiVirusesClinical Factors Associated with SFTS Diagnosis and Severity in Cats.PMC1120930522KK0115JP21fm020810121K07059JP21wm0325023JP23fm0208101JP23fm0208101, JP23fk0108656, JP23wm0125006, JP22wm0325023, JP22fm0208101, JP21fm0208101, JP21wm0325023, and JP20wm0323023JP22wm03250232022-Ippan-1221K07059 and 22KK01152022-Ippan-12 and 2023-Ippan-16JP23wm01250062023-Ippan-16JP23fk0108656JP20wm0323023JP22fm0208101Nwe KMInoue SMorita KXu QBalingit JCYu FTakamatsu YOsako HNabeshima THayasaka DNgwe Tun MMfalseClinical Factors Associated with SFTS Diagnosis and Severity in Cats.Severe fever with thrombocytopenia syndrome (SFTS) is a potentially fatal tick-borne zoonosis caused by SFTS virus (SFTSV). In addition to tick bites, animal-to-human transmission of SFTSV has been reported, but little is known about feline SFTSV infection. In this study, we analyzed data on 187 cats with suspected SFTS to identify biomarkers for SFTS diagnosis and clinical outcome. Body weight, red and white blood cell and platelet counts, and serum aspartate aminotransferase and total bilirubin levels were useful for SFTS diagnosis, whereas alanine aminotransferase, aspartate aminotransferase and serum SFTSV RNA levels were associated with clinical outcome. We developed a scoring model to predict SFTSV infection. In addition, we performed a phylogenetic analysis to reveal the relationshi2024-01-01T00:00:00Z2024 May2026-05-28T03:09:29.53Z2024-11-21T05:50:44.014ZS-EPMC112093053893216710.3390/v16060874