{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Leung WCY"],"pubmed_abstract":["Although Coronavirus disease 2019 (COVID-19) vaccinations are generally recommended for persons with epilepsy (PwE), a significant vaccination gap remains due to patient concerns over the risk of post-vaccination seizure aggravation (PVSA). In this single-centre, retrospective cohort study, we aimed to determine the early (7-day) and delayed (30-day) risk of PVSA, and to identify clinical predictors of PVSA among PwE. Adult epilepsy patients aged ≥18 years without a history of COVID-19 infection were recruited from a specialty epilepsy clinic in early 2022. Demographic, epilepsy characteristics, and vaccination data were extracted from a centralized electronic patient record. Seizure frequency before and after vaccination, vaccination-related adverse effects, and reasons for or against vac"],"journal":["Vaccines"],"pagination":["593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209536"],"repository":["biostudies-literature"],"pubmed_title":["Risk of Seizure Aggravation after COVID-19 Vaccinations in Patients with Epilepsy."],"pmcid":["PMC11209536"],"pubmed_authors":["Chui JHY","Yeung EHL","Teo KC","Chan CYC","Leung AK","Chan AA","Chu FH","Li WTV","Leung WCY","Lo CNR","Chang RS","Ho RW","Lau GK","Chan DYH"],"additional_accession":[]},"is_claimable":false,"name":"Risk of Seizure Aggravation after COVID-19 Vaccinations in Patients with Epilepsy.","description":"Although Coronavirus disease 2019 (COVID-19) vaccinations are generally recommended for persons with epilepsy (PwE), a significant vaccination gap remains due to patient concerns over the risk of post-vaccination seizure aggravation (PVSA). In this single-centre, retrospective cohort study, we aimed to determine the early (7-day) and delayed (30-day) risk of PVSA, and to identify clinical predictors of PVSA among PwE. Adult epilepsy patients aged ≥18 years without a history of COVID-19 infection were recruited from a specialty epilepsy clinic in early 2022. Demographic, epilepsy characteristics, and vaccination data were extracted from a centralized electronic patient record. Seizure frequency before and after vaccination, vaccination-related adverse effects, and reasons for or against vac","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-04-04T21:22:13.52Z","creation":"2025-04-04T21:22:13.52Z"},"accession":"S-EPMC11209536","cross_references":{"pubmed":["38932322"],"doi":["10.3390/vaccines12060593"]}}