biostudies-literatureUnknown12(6)Leung WCYAlthough Coronavirus disease 2019 (COVID-19) vaccinations are generally recommended for persons with epilepsy (PwE), a significant vaccination gap remains due to patient concerns over the risk of post-vaccination seizure aggravation (PVSA). In this single-centre, retrospective cohort study, we aimed to determine the early (7-day) and delayed (30-day) risk of PVSA, and to identify clinical predictors of PVSA among PwE. Adult epilepsy patients aged ≥18 years without a history of COVID-19 infection were recruited from a specialty epilepsy clinic in early 2022. Demographic, epilepsy characteristics, and vaccination data were extracted from a centralized electronic patient record. Seizure frequency before and after vaccination, vaccination-related adverse effects, and reasons for or against vacVaccines593https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209536biostudies-literatureRisk of Seizure Aggravation after COVID-19 Vaccinations in Patients with Epilepsy.PMC11209536Chui JHYYeung EHLTeo KCChan CYCLeung AKChan AAChu FHLi WTVLeung WCYLo CNRChang RSHo RWLau GKChan DYHfalseRisk of Seizure Aggravation after COVID-19 Vaccinations in Patients with Epilepsy.Although Coronavirus disease 2019 (COVID-19) vaccinations are generally recommended for persons with epilepsy (PwE), a significant vaccination gap remains due to patient concerns over the risk of post-vaccination seizure aggravation (PVSA). In this single-centre, retrospective cohort study, we aimed to determine the early (7-day) and delayed (30-day) risk of PVSA, and to identify clinical predictors of PVSA among PwE. Adult epilepsy patients aged ≥18 years without a history of COVID-19 infection were recruited from a specialty epilepsy clinic in early 2022. Demographic, epilepsy characteristics, and vaccination data were extracted from a centralized electronic patient record. Seizure frequency before and after vaccination, vaccination-related adverse effects, and reasons for or against vac2024-01-01T00:00:00Z2024 May2025-04-04T21:22:13.52Z2025-04-04T21:22:13.52ZS-EPMC112095363893232210.3390/vaccines12060593