{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gu J"],"funding":["Chongqing Science and Technology Commission"],"pagination":["442"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Bisphenol A (BPA), a typical endocrine disruptor, is known to have various adverse effects on the male reproductive system. However, the toxic effects and mechanisms of low-dose BPA have not yet been fully explored. In this study, male Kunming mice were orally administered low-dose BPA (0.03, 0.3 and 3 mg/kg/d) for ten consecutive weeks. Pathological sections of testicular tissue showed no significant morphological differences after BPA exposure. An analysis of the functional parameters of sperm revealed that exposure to low-dose BPA significantly decreased sperm motility, chemotaxis, and the acrosome reaction. An in vitro BPA exposure model combined with an omics data analysis showed that the olfactory receptor-related pathway was significantly enriched after BPA treatment. Subsequent exp"],"journal":["Toxics"],"pubmed_title":["The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-Ca<sup>2+</sup> Signaling Pathway."],"pmcid":["PMC11209571"],"funding_grant_id":["KJQN202212806","cstc2020jcyj-bshX0036"],"pubmed_authors":["Liu J","Zhu L","Jiang X","Sun S","Lou Y","Zhang N","Gu J","Yin L"],"additional_accession":[]},"is_claimable":false,"name":"The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-Ca<sup>2+</sup> Signaling Pathway.","description":"Bisphenol A (BPA), a typical endocrine disruptor, is known to have various adverse effects on the male reproductive system. However, the toxic effects and mechanisms of low-dose BPA have not yet been fully explored. In this study, male Kunming mice were orally administered low-dose BPA (0.03, 0.3 and 3 mg/kg/d) for ten consecutive weeks. Pathological sections of testicular tissue showed no significant morphological differences after BPA exposure. An analysis of the functional parameters of sperm revealed that exposure to low-dose BPA significantly decreased sperm motility, chemotaxis, and the acrosome reaction. An in vitro BPA exposure model combined with an omics data analysis showed that the olfactory receptor-related pathway was significantly enriched after BPA treatment. Subsequent exp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-20T02:16:11.099Z","creation":"2025-04-20T02:16:11.099Z"},"accession":"S-EPMC11209571","cross_references":{"pubmed":["38922122"],"doi":["10.3390/toxics12060442"]}}