{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(9)"],"submitter":["Zhou H"],"pubmed_abstract":["<b>Background:</b> The repair of osteoporotic bone defects remains challenging due to excessive reactive oxygen species (ROS), persistent inflammation, and an imbalance between osteogenesis and osteoclastogenesis. <b>Methods:</b> Here, an injectable H<sub>2</sub>-releasing hydrogel (magnesium@polyethylene glycol-poly(lactic-co-glycolic acid), Mg@PEG-PLGA) was developed to remodel the challenging bone environment and accelerate the repair of osteoporotic bone defects. <b>Results:</b> This Mg@PEG-PLGA gel shows excellent injectability, shape adaptability, and phase-transition ability, can fill irregular bone defect areas via minimally invasive injection, and can transform into a porous scaffold <i>in situ</i> to provide mechanical support. With the appropriate release of H<sub>2</sub> and magnesium ions, the 2Mg@PEG-PLGA gel (loaded with 2 mg of Mg) displayed significant immunomodulatory effects through reducing intracellular ROS, guiding macrophage polarization toward the M2 phenotype, and inhibiting the IκB/NF-κB signaling pathway. Moreover, <i>in vitro</i> experiments showed that the 2Mg@PEG-PLGA gel inhibited osteoclastogenesis while promoting osteogenesis. Most notably, in animal experiments, the 2Mg@PEG-PLGA gel significantly promoted the repair of osteoporotic bone defects <i>in vivo</i> by scavenging ROS and inhibiting inflammation and osteoclastogenesis. <b>Conclusions:</b> Overall, our study provides critical insight into the design and development of H<sub>2</sub>-releasing magnesium-based hydrogels as potential implants for repairing osteoporotic bone defects."],"journal":["Theranostics"],"pagination":["3739-3759"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209720"],"repository":["biostudies-literature"],"pubmed_title":["An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation."],"pmcid":["PMC11209720"],"pubmed_authors":["He Z","Cao Y","Deng Z","Zhou H","Chu L","Yu K","Liang B"],"additional_accession":[]},"is_claimable":false,"name":"An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation.","description":"<b>Background:</b> The repair of osteoporotic bone defects remains challenging due to excessive reactive oxygen species (ROS), persistent inflammation, and an imbalance between osteogenesis and osteoclastogenesis. <b>Methods:</b> Here, an injectable H<sub>2</sub>-releasing hydrogel (magnesium@polyethylene glycol-poly(lactic-co-glycolic acid), Mg@PEG-PLGA) was developed to remodel the challenging bone environment and accelerate the repair of osteoporotic bone defects. <b>Results:</b> This Mg@PEG-PLGA gel shows excellent injectability, shape adaptability, and phase-transition ability, can fill irregular bone defect areas via minimally invasive injection, and can transform into a porous scaffold <i>in situ</i> to provide mechanical support. With the appropriate release of H<sub>2</sub> and magnesium ions, the 2Mg@PEG-PLGA gel (loaded with 2 mg of Mg) displayed significant immunomodulatory effects through reducing intracellular ROS, guiding macrophage polarization toward the M2 phenotype, and inhibiting the IκB/NF-κB signaling pathway. Moreover, <i>in vitro</i> experiments showed that the 2Mg@PEG-PLGA gel inhibited osteoclastogenesis while promoting osteogenesis. Most notably, in animal experiments, the 2Mg@PEG-PLGA gel significantly promoted the repair of osteoporotic bone defects <i>in vivo</i> by scavenging ROS and inhibiting inflammation and osteoclastogenesis. <b>Conclusions:</b> Overall, our study provides critical insight into the design and development of H<sub>2</sub>-releasing magnesium-based hydrogels as potential implants for repairing osteoporotic bone defects.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-03-16T14:54:25.982Z","creation":"2025-08-15T03:07:05.897Z"},"accession":"S-EPMC11209720","cross_references":{"pubmed":["38948054"],"doi":["10.7150/thno.97412"]}}