{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wisch JK"],"funding":["NCATS NIH HHS","NIA NIH HHS","NIMH NIH HHS","NIHR Cambridge Biomedical Research Centre","Alzheimer&apos;s Association","National Institute of Child Health and Human Development","National Institute on Aging","Korea Ministry of Health and Welfare"],"pagination":["500-510"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209765"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(5)"],"pubmed_abstract":["<h4>Background</h4>In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. Studies including these cohorts could, therefore, improve our understanding of the early pathogenesis of Alzheimer's disease and be useful when designing preventive interventions targeted at disease pathology or when planning clinical trials. We compared the magnitude, spatial extent, and temporal ordering of tau spread in people with Down syndrome and autosomal-dominant Alzheimer's disease.<h4>Methods</h4>In this cross-sectional observational study, we included participants"],"journal":["The Lancet. Neurology"],"pubmed_title":["Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study."],"pmcid":["PMC11209765"],"funding_grant_id":["R01 AG052550","R56 AG053267","UF1 AG032438","U19 AG068054","UL1 TR001863","P30 AG072980","U19 AG032438","U01 AG042791","R01 AG053267","U01 AG051412","U01 AG051406","U01 AG079850","R01 AG046179","R01 MH120794","R61 AG066543","R01 AG062268"],"pubmed_authors":["Fox NC","Chhatwal JP","Zhang F","Clark L","Brooks WS","Rosas HD","Doran EW","Stauber J","Handen BL","Honig L","Reiman E","Laske C","Keator D","Pang D","Price JC","Herries E","Christian BT","Dominantly Inherited Alzheimer Network","Allegri RF","Daniels AJ","Bateman R","Xu J","Ramirez L","Cruchaga C","Gordon BA","Martins R","McKay NS","White DA","Pulsifer M","Xu X","Cash DM","Johnson ECB","Marsh J","Hornbeck R","Laymon CM","Mathis CA","Rizvi B","Salloway S","Tudorascu D","Courtney L","Gremminger E","Supnet-Bell C","Tycko B","Day G","Huey ED","Lott IT","Johnson SC","Jerome G","Ryan NS","Sabbagh MN","Constantino JN","Perrin RJ","Kuder-Buletta E","Foroud TM","Krinsky-McHale SJ","Rosa-Neto P","Minhas DS","Llibre-Guerra JJ","Ikeuchi T","Boerwinkle AH","Holtzman DM","Aguillon D","Rafii MS","Tumuluru R","Wisch JK","Ikonomovic S","Cohen A","Hartley SL","Kamboh MI","Schofield PR","Lao P","Lupson V","Yassa MA","Barthelemy N","Voglein J","Andrews HF","Hofmann A","Jucker M","Alzheimer's Biomarker Consortium-Down syndrome","Zaman S","Klunk WE","Noble JM","Schupf N","Brickman AM","Day GS","Cheema A","Nadkarni NK","Wang G","Bateman RJ","Nadkarni N","Bechara JA","Roedenbeck Y","Clare I","Graff-Radford NR","Niimi Y","Varadarajan B","Baker B","Berman SB","Graber-Sultan S","Benzinger T","Obermueller U","Seyfried NT","Ringman J","Karch CM","Farlow M","Birn RM","van Dyck CH","Llibre-Guerra J","Ringman JM","Lee JH","Mapstone M","Chen K","Feingold E","Zammit M","Tudorascu DL","Kennedy J","Ikonomovic MD","Li Y","Kreisl WC","Bulova P","Picarello DM","Flores S","Xiong C","Minton M","Chrem Mendez P","Head E","Renton AE","Lu R","Petersen M","Franklin E","Jordan C","Lai F","Chrem P","Ances BM","Stout S","Kasuga K","Mori H","Aizenstein HJ","Ibanez L","Goate AM","Vazquez S","Cohen AD","Hom C","Hassenstab J","Levey AI","Roh JH","Bird TD","McDade E","Daniels A","Morris JC","Smith J","Levin J","Bell K","Laymon C","Aschenbrenner AJ","Surace E","Kofler JK","O'Bryant SE","Sanchez-Valle R","Benzinger TLS","Lopera F","Leon YM"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study.","description":"<h4>Background</h4>In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. Studies including these cohorts could, therefore, improve our understanding of the early pathogenesis of Alzheimer's disease and be useful when designing preventive interventions targeted at disease pathology or when planning clinical trials. We compared the magnitude, spatial extent, and temporal ordering of tau spread in people with Down syndrome and autosomal-dominant Alzheimer's disease.<h4>Methods</h4>In this cross-sectional observational study, we included participants","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T20:58:04.347Z","creation":"2025-06-25T03:06:21.394Z"},"accession":"S-EPMC11209765","cross_references":{"pubmed":["38631766"],"doi":["10.1016/s1474-4422(24)00084-x","10.1016/S1474-4422(24)00084-X"]}}