biostudies-literatureFranklin MKNCATS NIH HHSNIA NIH HHSNHLBI NIH HHS1555-1569https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209774biostudies-literatureUnknown44(7)<h4>Background</h4>β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. The objective of this study was to define experimental parameters and determine whether equivalent or variable aortopathies were generated throughout the aortic tree during BAPN administration in mice.<h4>Methods</h4>BAPN was administered in drinking water for a period ranging from 1 to 12 weeks. The impacts of BAPN were first assessed with regard to BAPN dose, and mouse strain, age, and sex. BAPN-induced aortic pathological characterization was conducted using histology and immunostaining. To investigate the mechanistic basis of Arteriosclerosis, thrombosis, and vascular biologyβ-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice.PMC11209774R35 HL155649UL1 TR001998P30 AG072946Franklin MKGraf DBMoorleghen JJLu HSLiang CLAmioka NSawada HHowatt DAZhang NIto SDaugherty AKatsumata Yfalseβ-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice.<h4>Background</h4>β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. The objective of this study was to define experimental parameters and determine whether equivalent or variable aortopathies were generated throughout the aortic tree during BAPN administration in mice.<h4>Methods</h4>BAPN was administered in drinking water for a period ranging from 1 to 12 weeks. The impacts of BAPN were first assessed with regard to BAPN dose, and mouse strain, age, and sex. BAPN-induced aortic pathological characterization was conducted using histology and immunostaining. To investigate the mechanistic basis of 2024-01-01T00:00:00Z2024 Jul2026-06-03T07:30:24.673Z2026-04-25T03:22:54.19ZS-EPMC112097743877985610.1161/ATVBAHA.123.32040210.1161/atvbaha.123.320402