{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hong T"],"funding":["U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)","NIA NIH HHS","Leukemia and Lymphoma Society (Leukemia & Lymphoma Society)","U.S. Department of Health & Human Services | NIH | National Institute on Aging","NHLBI NIH HHS","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)","NIDDK NIH HHS","U.S. Department of Health & Human Services | NIH | National Cancer Institute","NCI NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)","Welch Foundation","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)","Leukemia and Lymphoma Society","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["1387-1400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11209854"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(11)"],"pubmed_abstract":["DNA methylation deregulation at partially methylated domains (PMDs) represents an epigenetic signature of aging and cancer, yet the underlying molecular basis and resulting biological consequences remain unresolved. We report herein a mechanistic link between disrupted DNA methylation at PMDs and the spatial relocalization of H3K9me3-marked heterochromatin in aged hematopoietic stem and progenitor cells (HSPCs) or those with impaired DNA methylation. We uncover that TET2 modulates the spatial redistribution of H3K9me3-marked heterochromatin to mediate the upregulation of endogenous retroviruses (ERVs) and interferon-stimulated genes (ISGs), hence contributing to functional decline of aged HSPCs. TET2-deficient HSPCs retain perinuclear distribution of heterochromatin and exhibit age-related"],"journal":["Nature aging"],"pubmed_title":["TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells."],"pmcid":["PMC11209854"],"funding_grant_id":["R35 HL166557","P30CA125123","BE-1913-20220331","LLS-TRP 6680-24","P01CA265748","R21 CA277257","R56 DK092883","P01 AG036695","R01CA232017","P30 CA125123","CA183252","R01CA240258","R01 CA232017","R01 DK092883","R35HL166557","DK092883","R21CA277257","P01AG036695","R01DK132286","R01 CA240258","R01 CA183252","P01 CA265748","R01 DK132286"],"pubmed_authors":["Rosas C","Li J","Wohlan K","Guzman A","Kapadia C","Zhou Y","Cheng X","DeLaFuente A","You MJ","Cavalier M","Dou Y","Guo L","Yang Y","Li S","Huang Y","Goodell MA","Wang T","Hong T","Fang S","Yin CC"],"additional_accession":[]},"is_claimable":false,"name":"TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.","description":"DNA methylation deregulation at partially methylated domains (PMDs) represents an epigenetic signature of aging and cancer, yet the underlying molecular basis and resulting biological consequences remain unresolved. We report herein a mechanistic link between disrupted DNA methylation at PMDs and the spatial relocalization of H3K9me3-marked heterochromatin in aged hematopoietic stem and progenitor cells (HSPCs) or those with impaired DNA methylation. We uncover that TET2 modulates the spatial redistribution of H3K9me3-marked heterochromatin to mediate the upregulation of endogenous retroviruses (ERVs) and interferon-stimulated genes (ISGs), hence contributing to functional decline of aged HSPCs. TET2-deficient HSPCs retain perinuclear distribution of heterochromatin and exhibit age-related","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-01T21:25:16.65Z","creation":"2025-04-04T21:22:14.546Z"},"accession":"S-EPMC11209854","cross_references":{"pubmed":["37884767"],"doi":["10.1038/s43587-023-00505-y"]}}