biostudies-literatureTalia MMinistero dell'Università e della RicercaMinistero della SaluteFondazione AIRC per la ricerca sul cancro ETSMinistero dell’Università e della Ricerca597https://www.ebi.ac.uk/biostudies/studies/S-EPMC11210052biostudies-literatureUnknown22(1)<h4>Background</h4>Over the last two decades, tumor-derived RNA expression signatures have been developed for the two most commonly diagnosed tumors worldwide, namely prostate and breast tumors, in order to improve both outcome prediction and treatment decision-making. In this context, molecular signatures gained by main components of the tumor microenvironment, such as cancer-associated fibroblasts (CAFs), have been explored as prognostic and therapeutic tools. Nevertheless, a deeper understanding of the significance of CAFs-related gene signatures in breast and prostate cancers still remains to be disclosed.<h4>Methods</h4>RNA sequencing technology (RNA-seq) was employed to profile and compare the transcriptome of CAFs isolated from patients affected by breast and prostate tumors. The diJournal of translational medicineCancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients.PMC11210052IG n. 23369Start-Up Grant 21651Prin 2022 PNRR P2022MALRPIG n. 27386Prin 2022 202282CMEARF-2019-12368937Prin 2022 2022Y79PT4Cirillo FCesario EMondino AATalia MBelfiore AMiglietta AMOcchiuzzi MADi Dio MScordamaglia DCapalbo CZicarelli ALappano RDe Francesco EMMaggiolini MfalseCancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients.<h4>Background</h4>Over the last two decades, tumor-derived RNA expression signatures have been developed for the two most commonly diagnosed tumors worldwide, namely prostate and breast tumors, in order to improve both outcome prediction and treatment decision-making. In this context, molecular signatures gained by main components of the tumor microenvironment, such as cancer-associated fibroblasts (CAFs), have been explored as prognostic and therapeutic tools. Nevertheless, a deeper understanding of the significance of CAFs-related gene signatures in breast and prostate cancers still remains to be disclosed.<h4>Methods</h4>RNA sequencing technology (RNA-seq) was employed to profile and compare the transcriptome of CAFs isolated from patients affected by breast and prostate tumors. The di2024-01-01T00:00:00Z2024 Jun2026-06-02T01:48:54.271Z2026-04-13T03:12:15.495ZS-EPMC112100523893775410.1186/s12967-024-05413-2