{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Corleone G"],"funding":["Associazione Italiana per la Ricerca sul Cancro"],"pagination":["179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11210131"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(1)"],"pubmed_abstract":["<h4>Background</h4>Enhancer reprogramming plays a significant role in the heterogeneity of cancer. However, we have limited knowledge about the impact of chromatin remodeling in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) patients, and how it affects tumorigenesis and drug response. Our research focuses on investigating the role of enhancers in sustaining oncogenic transformation in children with BCP-ALL.<h4>Methods</h4>We used ATAC-seq to study the accessibility of chromatin in pediatric BCP-ALL at three different stages-onset, remission, and relapse. Using a combination of computational and experimental methods, we were able to analyze the accessibility landscape and focus on the most significant cis-regulatory sites. These sites were then functionally validated through the u"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia."],"pmcid":["PMC11210131"],"funding_grant_id":["MFAG-20096","15255","I-CARE2 800924"],"pubmed_authors":["Folgiero V","Di Giovenale S","Caforio M","Fanciulli M","Cortile C","Corleone G","Locatelli F","Pitisci A","Goeman F","De Nicola F","Bertaina V","Sorino C"],"additional_accession":[]},"is_claimable":false,"name":"Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia.","description":"<h4>Background</h4>Enhancer reprogramming plays a significant role in the heterogeneity of cancer. However, we have limited knowledge about the impact of chromatin remodeling in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) patients, and how it affects tumorigenesis and drug response. Our research focuses on investigating the role of enhancers in sustaining oncogenic transformation in children with BCP-ALL.<h4>Methods</h4>We used ATAC-seq to study the accessibility of chromatin in pediatric BCP-ALL at three different stages-onset, remission, and relapse. Using a combination of computational and experimental methods, we were able to analyze the accessibility landscape and focus on the most significant cis-regulatory sites. These sites were then functionally validated through the u","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-04T21:21:51.877Z","creation":"2025-04-04T21:21:51.877Z"},"accession":"S-EPMC11210131","cross_references":{"pubmed":["38926853"],"doi":["10.1186/s13046-024-03075-y"]}}