{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nam DE"],"funding":["National Institutes of Health"],"pagination":["e0306345"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11210754"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(6)"],"pubmed_abstract":["Chronic liver diseases are caused by hepatic viral infection, chemicals, and metabolic stress. The protein Grb2-associated binder 1 (Gab1) binds to various growth factor receptors, and triggers cell differentiation/survival signaling pathways. To identify signaling molecules involved in the progression of liver diseases, we performed reverse-phase protein microarray (RPMA)-based screening of hepatocytes isolated from humanized mice after acute HCV infection. Acute viral infection in humanized liver mice significantly decreased the level of hepatocyte p-Gab1. Moreover, hepatoma cells upon HCV infection decreased Gab1 mRNA at later times of infection (D3 to D5) and p-Gab1 level was inversely related to the production of TGF-β. In contrast, the level of p-Gab1 was increased in CCL4-induced fi"],"journal":["PloS one"],"pubmed_title":["Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis."],"pmcid":["PMC11210754"],"funding_grant_id":["R42 AI122666-03","R01 Dk122737"],"pubmed_authors":["Hakami RM","Nam DE","Um E","Omole S","Hahn YS","Park SJ"],"additional_accession":[]},"is_claimable":false,"name":"Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis.","description":"Chronic liver diseases are caused by hepatic viral infection, chemicals, and metabolic stress. The protein Grb2-associated binder 1 (Gab1) binds to various growth factor receptors, and triggers cell differentiation/survival signaling pathways. To identify signaling molecules involved in the progression of liver diseases, we performed reverse-phase protein microarray (RPMA)-based screening of hepatocytes isolated from humanized mice after acute HCV infection. Acute viral infection in humanized liver mice significantly decreased the level of hepatocyte p-Gab1. Moreover, hepatoma cells upon HCV infection decreased Gab1 mRNA at later times of infection (D3 to D5) and p-Gab1 level was inversely related to the production of TGF-β. In contrast, the level of p-Gab1 was increased in CCL4-induced fi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-19T18:35:47.103Z","creation":"2025-04-19T18:35:47.103Z"},"accession":"S-EPMC11210754","cross_references":{"pubmed":["38935609"],"doi":["10.1371/journal.pone.0306345"]}}