biostudies-literatureUnknown20(1)Garcia AGlaxoSmithKlineThe recombinant zoster vaccine (RZV) is included in the Spanish National Immunisation Programme for adults 65 years of age (years), with a potential progressive catch-up program for adults 66-80 years, starting with 80 years. However, the risk of herpes zoster (HZ) increases significantly from 50 years. We estimated the public health impact (PHI) of vaccinating adults ≥50 years in Spain versus no vaccination, using a Markov model adapted to the Spanish setting. The model simulated a hypothetical ≥50 years cohort over a lifetime, with inputs from Spanish publications, databases, or publications from other countries where Spanish data were unavailable. Base case inputs included 67.7% RZV coverage and 61.1% second dose compliance. Outputs included clinical outcomes avoided, healthcare resourcHuman vaccines & immunotherapeutics2366353https://www.ebi.ac.uk/biostudies/studies/S-EPMC11210909biostudies-literatureThe public health impact of recombinant herpes zoster vaccination in adults over 50 years in Spain.PMC11210909Vallejo-Aparicio LACambronero Martinez RGarcia AfalseThe public health impact of recombinant herpes zoster vaccination in adults over 50 years in Spain.The recombinant zoster vaccine (RZV) is included in the Spanish National Immunisation Programme for adults 65 years of age (years), with a potential progressive catch-up program for adults 66-80 years, starting with 80 years. However, the risk of herpes zoster (HZ) increases significantly from 50 years. We estimated the public health impact (PHI) of vaccinating adults ≥50 years in Spain versus no vaccination, using a Markov model adapted to the Spanish setting. The model simulated a hypothetical ≥50 years cohort over a lifetime, with inputs from Spanish publications, databases, or publications from other countries where Spanish data were unavailable. Base case inputs included 67.7% RZV coverage and 61.1% second dose compliance. Outputs included clinical outcomes avoided, healthcare resourc2024-01-01T00:00:00Z2024 Dec2025-04-19T18:33:19.89Z2025-04-19T18:33:19.89ZS-EPMC112109093892514510.1080/21645515.2024.2366353