{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McIntire KM"],"funding":["Ministry of Education","NCATS NIH HHS","NIAID NIH HHS","Collaborative Influenza Vaccine Innovation Centers","National Institutes of Health","National Research Foundation of Korea","Centers of Excellence for Influenza Research and Response","NIH HHS","Centers of Excellence for Influenza Research and Surveillance"],"pagination":["e20240668"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11211068"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["221(8)"],"pubmed_abstract":["Germinal centers (GC) are microanatomical lymphoid structures where affinity-matured memory B cells and long-lived bone marrow plasma cells are primarily generated. It is unclear how the maturation of B cells within the GC impacts the breadth and durability of B cell responses to influenza vaccination in humans. We used fine needle aspiration of draining lymph nodes to longitudinally track antigen-specific GC B cell responses to seasonal influenza vaccination. Antigen-specific GC B cells persisted for at least 13 wk after vaccination in two out of seven individuals. Monoclonal antibodies (mAbs) derived from persisting GC B cell clones exhibit enhanced binding affinity and breadth to influenza hemagglutinin (HA) antigens compared with related GC clonotypes isolated earlier in the response. "],"journal":["The Journal of experimental medicine"],"pubmed_title":["Maturation of germinal center B cells after influenza virus vaccination in humans."],"pmcid":["PMC11211068"],"funding_grant_id":["U19AI089992","HHSN272201400008C","75N93019C00051","U01 AI144616","5T32AI007163-44","R01AI168178-01","U01 AI141990","UL1 TR001863","2021R1A6A3A03041509","U01 AI150747","5U01AI144616-02","R01AI104739","R01 AI104739","75N93021C00014","U01AI141990","T32 AI007163","U19 AI089992","1U01AI150747","R01 AI168178"],"pubmed_authors":["Turner JS","Zhou JQ","Yellin T","Wang M","Suessen T","Middleton WD","Krammer F","McIntire KM","Kleinstein SH","McMahon M","Malladi SK","Moore NE","Ward AB","Schmitz AJ","Ellebedy AH","Lin TH","Wilson IA","Kim W","Mohammed BM","Carreno JM","Presti RM","Han J","Teefey SA","Meng H","Hoehn KB"],"additional_accession":[]},"is_claimable":false,"name":"Maturation of germinal center B cells after influenza virus vaccination in humans.","description":"Germinal centers (GC) are microanatomical lymphoid structures where affinity-matured memory B cells and long-lived bone marrow plasma cells are primarily generated. It is unclear how the maturation of B cells within the GC impacts the breadth and durability of B cell responses to influenza vaccination in humans. We used fine needle aspiration of draining lymph nodes to longitudinally track antigen-specific GC B cell responses to seasonal influenza vaccination. Antigen-specific GC B cells persisted for at least 13 wk after vaccination in two out of seven individuals. Monoclonal antibodies (mAbs) derived from persisting GC B cell clones exhibit enhanced binding affinity and breadth to influenza hemagglutinin (HA) antigens compared with related GC clonotypes isolated earlier in the response. ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-01T18:09:36.949Z","creation":"2025-04-03T23:44:23.204Z"},"accession":"S-EPMC11211068","cross_references":{"pubmed":["38935072"],"doi":["10.1084/jem.20240668"]}}