{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choa R"],"funding":["NIAID NIH HHS","University of Pennsylvania","NHLBI NIH HHS","National Institutes of Health","NIAMS NIH HHS"],"pagination":["480-491"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11211244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["154(2)"],"pubmed_abstract":["<h4>Background</h4>The cytokine TSLP promotes type 2 immune responses and can induce adipose loss by stimulating lipid loss from the skin through sebum secretion by sebaceous glands, which enhances the skin barrier. However, the mechanism by which TSLP upregulates sebaceous gland function is unknown.<h4>Objectives</h4>This study investigated the mechanism by which TSLP stimulates sebum secretion and adipose loss.<h4>Methods</h4>RNA-sequencing analysis was performed on sebaceous glands isolated by laser capture microdissection and single-cell RNA-sequencing analysis was performed on sorted skin T cells. Sebocyte function was analyzed by histological analysis and sebum secretion in vivo and by measuring lipogenesis and proliferation in vitro.<h4>Results</h4>This study found that TSLP sequent"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Thymic stromal lymphopoietin induces IL-4/IL-13 from T cells to promote sebum secretion and adipose loss."],"pmcid":["PMC11211244"],"funding_grant_id":["T32 HL007439","F31 AR079845","R01 AR082256","T32 AR007465","R01-AR070116","P30 AR069589","R01 HL111501","T32-AR007465","F31-AR079845","R01-HL111501","T32-HL07439","R01-AI121250","R01 AR070116","R01 AI121250"],"pubmed_authors":["Kambayashi T","To J","Yokoyama Y","Okumura M","Harris JC","Choa R","Nelson A","Lou M","Kim M","Yang E"],"additional_accession":[]},"is_claimable":false,"name":"Thymic stromal lymphopoietin induces IL-4/IL-13 from T cells to promote sebum secretion and adipose loss.","description":"<h4>Background</h4>The cytokine TSLP promotes type 2 immune responses and can induce adipose loss by stimulating lipid loss from the skin through sebum secretion by sebaceous glands, which enhances the skin barrier. However, the mechanism by which TSLP upregulates sebaceous gland function is unknown.<h4>Objectives</h4>This study investigated the mechanism by which TSLP stimulates sebum secretion and adipose loss.<h4>Methods</h4>RNA-sequencing analysis was performed on sebaceous glands isolated by laser capture microdissection and single-cell RNA-sequencing analysis was performed on sorted skin T cells. Sebocyte function was analyzed by histological analysis and sebum secretion in vivo and by measuring lipogenesis and proliferation in vitro.<h4>Results</h4>This study found that TSLP sequent","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-17T15:32:15.142Z","creation":"2025-08-16T03:06:55.136Z"},"accession":"S-EPMC11211244","cross_references":{"pubmed":["38157943"],"doi":["10.1016/j.jaci.2023.11.923"]}}