{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chun SG"],"funding":["NCI NIH HHS"],"pagination":["1111-1115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11211986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(8)"],"pubmed_abstract":["<h4>Importance</h4>The optimal radiotherapy technique for unresectable locally advanced non-small cell lung cancer (NSCLC) is controversial, so evaluating long-term prospective outcomes of intensity-modulated radiotherapy (IMRT) is important.<h4>Objective</h4>To compare long-term prospective outcomes of patients receiving IMRT and 3-dimensional conformal radiotherapy (3D-CRT) with concurrent carboplatin/paclitaxel for locally advanced NSCLC.<h4>Design, setting, and participants</h4>A secondary analysis of a prospective phase 3 randomized clinical trial NRG Oncology-RTOG 0617 assessed 483 patients receiving chemoradiotherapy (3D-CRT vs IMRT) for locally advanced NSCLC based on stratification.<h4>Main outcomes and measures</h4>Long-term outcomes were analyzed, including overall survival (OS)"],"journal":["JAMA oncology"],"pubmed_title":["Long-Term Prospective Outcomes of Intensity Modulated Radiotherapy for Locally Advanced Lung Cancer: A Secondary Analysis of a Randomized Clinical Trial."],"pmcid":["PMC11211986"],"funding_grant_id":["R50 CA275822","P30 CA008748","U10 CA180868","U10 CA180822","UG1 CA233330"],"pubmed_authors":["Kavadi VS","Bogart JA","Raben A","Dobelbower MC","Chun SG","Bosch W","Augspurger ME","Schild SE","Hu C","Paulus R","Rothman J","Bradley JD","MacRae RM","Narayan S","Iyengar P","Robinson C","Timmerman RD","Komaki RU"],"additional_accession":[]},"is_claimable":false,"name":"Long-Term Prospective Outcomes of Intensity Modulated Radiotherapy for Locally Advanced Lung Cancer: A Secondary Analysis of a Randomized Clinical Trial.","description":"<h4>Importance</h4>The optimal radiotherapy technique for unresectable locally advanced non-small cell lung cancer (NSCLC) is controversial, so evaluating long-term prospective outcomes of intensity-modulated radiotherapy (IMRT) is important.<h4>Objective</h4>To compare long-term prospective outcomes of patients receiving IMRT and 3-dimensional conformal radiotherapy (3D-CRT) with concurrent carboplatin/paclitaxel for locally advanced NSCLC.<h4>Design, setting, and participants</h4>A secondary analysis of a prospective phase 3 randomized clinical trial NRG Oncology-RTOG 0617 assessed 483 patients receiving chemoradiotherapy (3D-CRT vs IMRT) for locally advanced NSCLC based on stratification.<h4>Main outcomes and measures</h4>Long-term outcomes were analyzed, including overall survival (OS)","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-01T12:02:51.92Z","creation":"2026-04-08T12:00:48.264Z"},"accession":"S-EPMC11211986","cross_references":{"pubmed":["38935373"],"doi":["10.1001/jamaoncol.2024.1841"]}}