biostudies-literatureChun SGNCI NIH HHS1111-1115https://www.ebi.ac.uk/biostudies/studies/S-EPMC11211986biostudies-literatureUnknown10(8)<h4>Importance</h4>The optimal radiotherapy technique for unresectable locally advanced non-small cell lung cancer (NSCLC) is controversial, so evaluating long-term prospective outcomes of intensity-modulated radiotherapy (IMRT) is important.<h4>Objective</h4>To compare long-term prospective outcomes of patients receiving IMRT and 3-dimensional conformal radiotherapy (3D-CRT) with concurrent carboplatin/paclitaxel for locally advanced NSCLC.<h4>Design, setting, and participants</h4>A secondary analysis of a prospective phase 3 randomized clinical trial NRG Oncology-RTOG 0617 assessed 483 patients receiving chemoradiotherapy (3D-CRT vs IMRT) for locally advanced NSCLC based on stratification.<h4>Main outcomes and measures</h4>Long-term outcomes were analyzed, including overall survival (OS)JAMA oncologyLong-Term Prospective Outcomes of Intensity Modulated Radiotherapy for Locally Advanced Lung Cancer: A Secondary Analysis of a Randomized Clinical Trial.PMC11211986R50 CA275822P30 CA008748U10 CA180868U10 CA180822UG1 CA233330Kavadi VSBogart JARaben ADobelbower MCChun SGBosch WAugspurger MESchild SEHu CPaulus RRothman JBradley JDMacRae RMNarayan SIyengar PRobinson CTimmerman RDKomaki RUfalseLong-Term Prospective Outcomes of Intensity Modulated Radiotherapy for Locally Advanced Lung Cancer: A Secondary Analysis of a Randomized Clinical Trial.<h4>Importance</h4>The optimal radiotherapy technique for unresectable locally advanced non-small cell lung cancer (NSCLC) is controversial, so evaluating long-term prospective outcomes of intensity-modulated radiotherapy (IMRT) is important.<h4>Objective</h4>To compare long-term prospective outcomes of patients receiving IMRT and 3-dimensional conformal radiotherapy (3D-CRT) with concurrent carboplatin/paclitaxel for locally advanced NSCLC.<h4>Design, setting, and participants</h4>A secondary analysis of a prospective phase 3 randomized clinical trial NRG Oncology-RTOG 0617 assessed 483 patients receiving chemoradiotherapy (3D-CRT vs IMRT) for locally advanced NSCLC based on stratification.<h4>Main outcomes and measures</h4>Long-term outcomes were analyzed, including overall survival (OS)2024-01-01T00:00:00Z2024 Aug2026-06-01T12:02:51.92Z2026-04-08T12:00:48.264ZS-EPMC112119863893537310.1001/jamaoncol.2024.1841