{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lv Y"],"funding":["NIA NIH HHS","National Institutes of Health","NIH HHS","National Natural Sciences Foundation of China"],"pagination":["2145-2154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11212828"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(24)"],"pubmed_abstract":["Background and aims
Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) and health among the oldest-old (aged ≥80 years), as an inverse relationship of BMI with mortality was reported. This study was to investigate the causal associations of BMI, waist circumference (WC), or both with mortality in the oldest-old people in China.Methods
A total of 5306 community-based oldest-old (mean age 90.6 years) were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 1998 and 2018. Genetic risk scores were constructed from 58 single-nucleotide polymorphisms (SNPs) associated with BMI and 49 SNPs associated with WC to subsequently derive causal estimates for Mendelian randomization (MR) models. One-sample linear MR "],"journal":["European heart journal"],"pubmed_title":["Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study."],"pmcid":["PMC11212828"],"funding_grant_id":["P30-AG028716","82222063","P30 AG028716","82025030","81941023"],"pubmed_authors":["Guo Y","Lv Y","Ren Y","Yu Q","Wu B","Deng L","Wei Y","Wang J","Shi X","Qiu Y","Kraus VB","Zhou J","Xu L","Tong S","Li C","Cui X","Zeng Y","Chen C","Yin Z","Li X","Ye L","Mao C","Lu H","Zhang Y","Luo Y","Gao X","Xu Z"],"additional_accession":[]},"is_claimable":false,"name":"Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study.","description":"Background and aims
Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) and health among the oldest-old (aged ≥80 years), as an inverse relationship of BMI with mortality was reported. This study was to investigate the causal associations of BMI, waist circumference (WC), or both with mortality in the oldest-old people in China.Methods
A total of 5306 community-based oldest-old (mean age 90.6 years) were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 1998 and 2018. Genetic risk scores were constructed from 58 single-nucleotide polymorphisms (SNPs) associated with BMI and 49 SNPs associated with WC to subsequently derive causal estimates for Mendelian randomization (MR) models. One-sample linear MR ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-07-26T03:06:56.687Z","creation":"2025-07-08T03:10:50.403Z"},"accession":"S-EPMC11212828","cross_references":{"pubmed":["38626306"],"doi":["10.1093/eurheartj/ehae206"]}}