{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Jonaitis J"],"funding":["NIDA NIH HHS","NINDS NIH HHS","Wellcome Trust"],"pubmed_abstract":["Understanding how animals coordinate movements to achieve goals is a fundamental pursuit in neuroscience. Here we explore how neurons that reside in posterior lower-order regions of a locomotor system project to anterior higher-order regions to influence steering and navigation. We characterized the anatomy and functional role of a population of ascending interneurons in the ventral nerve cord of <i>Drosophila</i> larvae. Through electron microscopy reconstructions and light microscopy, we determined that the cholinergic 19f cells receive input primarily from premotor interneurons and synapse upon a diverse array of postsynaptic targets within the anterior segments including other 19f cells. Calcium imaging of 19f activity in isolated central nervous system (CNS) preparations in relation t"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.06.17.598162"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11212907"],"repository":["biostudies-literature"],"pubmed_title":["STEERING FROM THE REAR: COORDINATION OF CENTRAL PATTERN GENERATORS UNDERLYING NAVIGATION BY ASCENDING INTERNEURONS."],"pmcid":["PMC11212907"],"funding_grant_id":["R13 DA034437","R01 NS105748"],"pubmed_authors":["Hiramoto A","McCafferty Layte K","Jonaitis J","Zwart MF","Hibbard KL","Cardona A","Truman JW","Nose A","Pulver SR"],"additional_accession":[]},"is_claimable":false,"name":"STEERING FROM THE REAR: COORDINATION OF CENTRAL PATTERN GENERATORS UNDERLYING NAVIGATION BY ASCENDING INTERNEURONS.","description":"Understanding how animals coordinate movements to achieve goals is a fundamental pursuit in neuroscience. Here we explore how neurons that reside in posterior lower-order regions of a locomotor system project to anterior higher-order regions to influence steering and navigation. We characterized the anatomy and functional role of a population of ascending interneurons in the ventral nerve cord of <i>Drosophila</i> larvae. Through electron microscopy reconstructions and light microscopy, we determined that the cholinergic 19f cells receive input primarily from premotor interneurons and synapse upon a diverse array of postsynaptic targets within the anterior segments including other 19f cells. Calcium imaging of 19f activity in isolated central nervous system (CNS) preparations in relation t","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-26T05:39:56.13Z","creation":"2025-04-06T11:39:03.399Z"},"accession":"S-EPMC11212907","cross_references":{"pubmed":["38948859"],"doi":["10.1101/2024.06.17.598162"]}}