{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao S"],"funding":["Kenneth Rainin Foundation","Crohn’s and Colitis Foundation","NIDDK NIH HHS","Crohn's & Colitis Foundation","NIH"],"pagination":["e174198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11214543"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134(13)"],"pubmed_abstract":["Group 3 innate lymphoid cells (ILC3s) are key players in intestinal homeostasis. ER stress is linked to inflammatory bowel disease (IBD). Here, we used cell culture, mouse models, and human specimens to determine whether ER stress in ILC3s affects IBD pathophysiology. We show that mouse intestinal ILC3s exhibited a 24-hour rhythmic expression pattern of the master ER stress response regulator inositol-requiring kinase 1α/X-box-binding protein 1 (IRE1α/XBP1). Proinflammatory cytokine IL-23 selectively stimulated IRE1α/XBP1 in mouse ILC3s through mitochondrial ROS (mtROS). IRE1α/XBP1 was activated in ILC3s from mice exposed to experimental colitis and in inflamed human IBD specimens. Mice with Ire1α deletion in ILC3s (Ire1αΔRorc) showed reduced expression of the ER stress response and cytoki"],"journal":["The Journal of clinical investigation"],"pubmed_title":["The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease."],"pmcid":["PMC11214543"],"funding_grant_id":["CCF1062472","1K08DK140612","K08 DK140612","T32 DK007130","DK126969","R01 DK126969","R01 DK132327","DK132327","P30 DK052574","KRA000141","1062472"],"pubmed_authors":["Ulezko Antonova A","Deepak P","Fachi JL","Wang Q","Kaufman RJ","Cai Z","Colonna M","Cao S","Ma K","Ciorba MA"],"additional_accession":[]},"is_claimable":false,"name":"The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease.","description":"Group 3 innate lymphoid cells (ILC3s) are key players in intestinal homeostasis. ER stress is linked to inflammatory bowel disease (IBD). Here, we used cell culture, mouse models, and human specimens to determine whether ER stress in ILC3s affects IBD pathophysiology. We show that mouse intestinal ILC3s exhibited a 24-hour rhythmic expression pattern of the master ER stress response regulator inositol-requiring kinase 1α/X-box-binding protein 1 (IRE1α/XBP1). Proinflammatory cytokine IL-23 selectively stimulated IRE1α/XBP1 in mouse ILC3s through mitochondrial ROS (mtROS). IRE1α/XBP1 was activated in ILC3s from mice exposed to experimental colitis and in inflamed human IBD specimens. Mice with Ire1α deletion in ILC3s (Ire1αΔRorc) showed reduced expression of the ER stress response and cytoki","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-03T02:40:20.315Z","creation":"2026-04-23T03:10:36.902Z"},"accession":"S-EPMC11214543","cross_references":{"pubmed":["38722686"],"doi":["10.1172/JCI174198"]}}