biostudies-literatureUnknown9(6)Hoang TCT<h4>Background</h4>The impact of the most recent advances, including targeted therapies and immune checkpoint inhibitors, on early (3-month) mortality in lung cancer is unknown. The aims of this study were to evaluate the real-world rate of and risk factors for early mortality, as well as trends in early mortality over the last 20 years.<h4>Materials and methods</h4>The KBP prospective observational multicenter studies have been conducted every 10 years since 2000. These studies collect data on all newly diagnosed patients with lung cancer (all stages and histologies) over 1 year in non-academic public hospital pulmonology or oncology units in France. In this study, we analyzed data on patient and tumor characteristics from participants in the KBP-2020 cohort and compared the characteristiESMO open103594https://www.ebi.ac.uk/biostudies/studies/S-EPMC11214995biostudies-literatureRisk factors for early mortality from lung cancer: evolution over the last 20 years in the French nationwide KBP cohorts.PMC11214995Patrick DChristophe PHerve POlivier LOlivier MMarielle STredaniel JJean-Yves TOlivier BFrederic BAsselain BBenoit GPatrick Aldo RPierre-Alexandre HLidia PClaire AFanny MSylvie JMarjorie PSophie SAnne-Sophie BLCyril MDemontrond PVirginie LAnne-Sophie BJean-Michel PMarguerite LDJarjour BClaudia RGeoffroy MFSeverine TRym HChantal DHannah GTYannick DEric GKevin FFaraj AFEric BJean-Marc DMarquette DMarie BCharles DGonzague CPhilippe SJacky CRomain CMaud RHugues MCatherine MPhilippe MNicolae BThierry SLaetitia CVanessa PIssam BThomas LAcya BTPascal BAmrane KLocher CHugues FCecile MJerome VJacques LTColette VDorine TCecile DMohamad JVincent TKarim ALaurence TDuval YFlorence LAmelie THauss PACortot AJulie OJaafar MHong RCouraud SLaurent MEmmanuelle LPierre KMolinier OLaurent PJoelle CLLaure BChristine LFethi EKCaroline CSebastien LReda CChristine DFrancois CIsabelle MEdith MJean Philippe KChristina DFrancois GDidier DAntoine BLionel FAlexandra BMeyer NAndreea TPhilippe BBenedicte MMarie TAnne-Marie CBertrand DKheir Eddine BEtienne ASoraya BPierre DSerge JLionel MDebieuvre DMarion NBaihas JChrystele LMartinez SStephanie MBravard ASElise RLe Garff GJulian PStephanie DMihai PAlexa MMagalie PTurlotte ADavid RDavid MSandrine LVMasson PStudy Group KBP-2020-CPHGDavid NMorel HTiercin MTemplement-Grangerat DChristian DLuc SHerve LFFatima MJeandeau SClothilde MWaad ASHoang TCTPetit LJean QGwenaelle LGJean-Bernard AFalchero LJean TfalseRisk factors for early mortality from lung cancer: evolution over the last 20 years in the French nationwide KBP cohorts.<h4>Background</h4>The impact of the most recent advances, including targeted therapies and immune checkpoint inhibitors, on early (3-month) mortality in lung cancer is unknown. The aims of this study were to evaluate the real-world rate of and risk factors for early mortality, as well as trends in early mortality over the last 20 years.<h4>Materials and methods</h4>The KBP prospective observational multicenter studies have been conducted every 10 years since 2000. These studies collect data on all newly diagnosed patients with lung cancer (all stages and histologies) over 1 year in non-academic public hospital pulmonology or oncology units in France. In this study, we analyzed data on patient and tumor characteristics from participants in the KBP-2020 cohort and compared the characteristi2024-01-01T00:00:00Z2024 Jun2025-04-18T15:28:49.688Z2025-04-07T02:11:05.518ZS-EPMC112149953884866110.1016/j.esmoop.2024.103594