biostudies-literatureGonzalez-Garcia JEuropean Union's Horizon 2020 research and innovation programmeEuropean Union’s Horizon 2020 research and innovation programmei43-i49https://www.ebi.ac.uk/biostudies/studies/S-EPMC11215320biostudies-literatureUnknown34(Supplement_1)<h4>Background</h4>The extensive and continuous reuse of sensitive health data could enhance the role of population health research on public decisions. This paper describes the design principles and the different building blocks that have supported the implementation and deployment of Population Health Information Research Infrastructure (PHIRI), the strengths and challenges of the approach and some future developments.<h4>Methods</h4>The design and implementation of PHIRI have been developed upon: (i) the data visiting principle-data does not move but code moves; (ii) the orchestration of the research question throughout a workflow that ensured legal, organizational, semantic and technological interoperability and (iii) a 'master-worker' federated computational architecture that supporteEuropean journal of public healthPHIRI: lessons for an extensive reuse of sensitive data in federated health research.PMC11215320101018317Estupinan-Romero FRodriguez-Blazquez CTelleria-Orriols CBogaert PGissler MSchmidt APopulation Health Information Research InfrastructureGonzalez-Galindo JZeitlin JPhilibert MGonzalez-Garcia JThißen MBernal-Delgado EDerycke PLyons RADolanski-Aghamanoukjan LSchutte NAldridge STolonen HfalsePHIRI: lessons for an extensive reuse of sensitive data in federated health research.<h4>Background</h4>The extensive and continuous reuse of sensitive health data could enhance the role of population health research on public decisions. This paper describes the design principles and the different building blocks that have supported the implementation and deployment of Population Health Information Research Infrastructure (PHIRI), the strengths and challenges of the approach and some future developments.<h4>Methods</h4>The design and implementation of PHIRI have been developed upon: (i) the data visiting principle-data does not move but code moves; (ii) the orchestration of the research question throughout a workflow that ensured legal, organizational, semantic and technological interoperability and (iii) a 'master-worker' federated computational architecture that supporte2024-01-01T00:00:00Z2024 Jul2025-04-18T15:28:04.072Z2025-04-07T02:06:39.763ZS-EPMC112153203894644710.1093/eurpub/ckae036