{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marchal A"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NIH"],"pagination":["100300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11215417"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(3)"],"pubmed_abstract":["Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COV"],"journal":["HGG advances"],"pubmed_title":["Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection."],"pmcid":["PMC11215417"],"funding_grant_id":["R01 AI163029","UL1 TR001866"],"pubmed_authors":["Foti G","Sancho-Shimizu V","Laverdant B","Arquero MF","van der Poll T","COVIDeF Study Group","Accordino G","Collet M","Carrabba M","Hraiech S","Wouters D","Etxart Lasa MP","Gagro A","Benkhelouf A","Bulle E","Derridj N","Klocperk A","Furet T","Rodriguez-Gallego C","Blanche P","Horn J","Saks K","Arlet JB","Horcajada JP","Taupin JL","Sukumar G","Vught LA","Redin C","Spaan AN","Pape JW","Cordel H","Manivet P","Ghezal M","Desguerre I","Gibelin A","Lacombe K","Schluter A","Stepanovskiy Y","Audiffred L","Citerio G","Theodose I","Arzoine J","Berard L","Drouet E","Jimeno MT","Sacleux SC","Laine F","Cao A","Bouziri N","Vedie 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Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COV","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-29T10:04:34.678Z","creation":"2025-04-07T02:07:28.793Z"},"accession":"S-EPMC11215417","cross_references":{"pubmed":["38678364"],"doi":["10.1016/j.xhgg.2024.100300"]}}