{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["79(7)"],"submitter":["Altarawneh H"],"funding":["Ministry of Education","Fudan University","University of Mutah"],"pubmed_abstract":["<h4>Objectives</h4>MRSA is a major cause of hospital-acquired and community-acquired infections. Treatment options for MRSA are limited because of the rapid development of β-lactam resistance. Combining antibiotics offers an affordable, time-saving, viable and efficient approach for developing novel antimicrobial therapies. Both amoxicillin and cefdinir are oral β-lactams with indications for a wide range of bacterial infections and mild side effects. This study aimed to investigate the in vitro and in vivo efficacy of combining these two β-lactams against MRSA strains.<h4>Methods</h4>Fourteen representative prevalent MRSA strains with diverse sequence types (STs) were tested with a combination of amoxicillin and cefdinir, using chequerboard and time-kill assays. The Galleria mellonella la"],"journal":["The Journal of antimicrobial chemotherapy"],"pagination":["1677-1682"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11215534"],"repository":["biostudies-literature"],"pubmed_title":["Synergistic bactericidal activity of a novel dual β-lactam combination against methicillin-resistant Staphylococcus aureus."],"pmcid":["PMC11215534"],"pubmed_authors":["Alharbi M","Fan Y","Altarawneh H","Alhomra T","Derrick JP","Xia G"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic bactericidal activity of a novel dual β-lactam combination against methicillin-resistant Staphylococcus aureus.","description":"<h4>Objectives</h4>MRSA is a major cause of hospital-acquired and community-acquired infections. Treatment options for MRSA are limited because of the rapid development of β-lactam resistance. Combining antibiotics offers an affordable, time-saving, viable and efficient approach for developing novel antimicrobial therapies. Both amoxicillin and cefdinir are oral β-lactams with indications for a wide range of bacterial infections and mild side effects. This study aimed to investigate the in vitro and in vivo efficacy of combining these two β-lactams against MRSA strains.<h4>Methods</h4>Fourteen representative prevalent MRSA strains with diverse sequence types (STs) were tested with a combination of amoxicillin and cefdinir, using chequerboard and time-kill assays. The Galleria mellonella la","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-18T15:28:28.629Z","creation":"2025-04-07T02:10:51.485Z"},"accession":"S-EPMC11215534","cross_references":{"pubmed":["38831599"],"doi":["10.1093/jac/dkae165"]}}