{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(6)"],"submitter":["Qi J"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["High myopia is a leading cause of blindness worldwide, among which pathologic myopia, characterized by typical myopic macular degeneration, is the most detrimental. However, its pathogenesis remains largely unknown. Here, using a HuProt array, we first initiated a serological autoantibody profiling of high myopia and identified 18 potential autoantibodies, of which anti-LIMS1 autoantibody was validated by a customized focused microarray. Further subgroup analysis revealed its actual relevance to pathologic myopia, rather than simple high myopia without myopic macular degeneration. Mechanistically, anti-LIMS1 autoantibody predominantly belonged to IgG1/IgG2/IgG3 subclasses. Serum IgG obtained from patients with pathologic myopia could disrupt the barrier function of retinal pigment epitheli"],"journal":["Molecular & cellular proteomics : MCP"],"pagination":["100783"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11215957"],"repository":["biostudies-literature"],"pubmed_title":["Circulating Autoantibody Profiling Identifies LIMS1 as a Potential Target for Pathogenic Autoimmunity in pathologic Myopia."],"pmcid":["PMC11215957"],"pubmed_authors":["Li H","Liu Y","Qi J","Zhang K","He W","Lu Y","Du Y","Zhu X","Meng J","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Circulating Autoantibody Profiling Identifies LIMS1 as a Potential Target for Pathogenic Autoimmunity in pathologic Myopia.","description":"High myopia is a leading cause of blindness worldwide, among which pathologic myopia, characterized by typical myopic macular degeneration, is the most detrimental. However, its pathogenesis remains largely unknown. Here, using a HuProt array, we first initiated a serological autoantibody profiling of high myopia and identified 18 potential autoantibodies, of which anti-LIMS1 autoantibody was validated by a customized focused microarray. Further subgroup analysis revealed its actual relevance to pathologic myopia, rather than simple high myopia without myopic macular degeneration. Mechanistically, anti-LIMS1 autoantibody predominantly belonged to IgG1/IgG2/IgG3 subclasses. Serum IgG obtained from patients with pathologic myopia could disrupt the barrier function of retinal pigment epitheli","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-07-15T10:26:11.001Z","creation":"2025-04-07T02:10:46.564Z"},"accession":"S-EPMC11215957","cross_references":{"pubmed":["38729610"],"doi":["10.1016/j.mcpro.2024.100783"]}}