biostudies-literatureKillanin ADNIMH NIH HHSNational Institute of Mental HealthNational Institute of General Medical SciencesNIGMS NIH HHSNational Science Foundatione26774https://www.ebi.ac.uk/biostudies/studies/S-EPMC11215982biostudies-literatureUnknown45(10)Testosterone levels sharply rise during the transition from childhood to adolescence and these changes are known to be associated with changes in human brain structure. During this same developmental window, there are also robust changes in the neural oscillatory dynamics serving verbal working memory processing. Surprisingly, whereas many studies have investigated the effects of chronological age on the neural oscillations supporting verbal working memory, none have probed the impact of endogenous testosterone levels during this developmental period. Using a sample of 89 youth aged 6-14 years-old, we collected salivary testosterone samples and recorded magnetoencephalography during a modified Sternberg verbal working memory task. Significant oscillatory responses were identified and imageHuman brain mappingEffects of endogenous testosterone on oscillatory activity during verbal working memory in youth.PMC11215982R01‐MH121101P20-GM144641R01-MH121101F30‐MH130150P20‐GM1446412112455F30-MH130150Embury CMWilson TWStephen JMWang YPPicci GKillanin ADCalhoun VDHeinrichs-Graham EWard TWfalseEffects of endogenous testosterone on oscillatory activity during verbal working memory in youth.Testosterone levels sharply rise during the transition from childhood to adolescence and these changes are known to be associated with changes in human brain structure. During this same developmental window, there are also robust changes in the neural oscillatory dynamics serving verbal working memory processing. Surprisingly, whereas many studies have investigated the effects of chronological age on the neural oscillations supporting verbal working memory, none have probed the impact of endogenous testosterone levels during this developmental period. Using a sample of 89 youth aged 6-14 years-old, we collected salivary testosterone samples and recorded magnetoencephalography during a modified Sternberg verbal working memory task. Significant oscillatory responses were identified and image2024-01-01T00:00:00Z2024 Jul2025-04-22T12:07:19.621Z2025-04-06T00:12:28.047ZS-EPMC112159823894959910.1002/hbm.26774