biostudies-literatureUnknown20Mari GA new class of heterocyclic <i>N</i>,<i>O</i>-aminal and hemiaminal scaffolds was successfully obtained by means of a three-component reaction (3-CR) of 1,2-diaza-1,3-dienes (DDs), α-aminoacetals and iso(thio)cyanates. These stable imine surrogates are generated from key-substituted (thio)hydantoin intermediates through selective FeCl₃-catalyzed intramolecular <i>N</i>-annulation.Beilstein journal of organic chemistry1412-1420https://www.ebi.ac.uk/biostudies/studies/S-EPMC11216082biostudies-literatureChallenge <i>N</i>- versus <i>O</i>-six-membered annulation: FeCl₃-catalyzed synthesis of heterocyclic <i>N</i>,<i>O</i>-aminals.PMC11216082Mari GFavi GOlivieri DSanteusanio SMantellini FDe Crescentini LfalseChallenge <i>N</i>- versus <i>O</i>-six-membered annulation: FeCl₃-catalyzed synthesis of heterocyclic <i>N</i>,<i>O</i>-aminals.A new class of heterocyclic <i>N</i>,<i>O</i>-aminal and hemiaminal scaffolds was successfully obtained by means of a three-component reaction (3-CR) of 1,2-diaza-1,3-dienes (DDs), α-aminoacetals and iso(thio)cyanates. These stable imine surrogates are generated from key-substituted (thio)hydantoin intermediates through selective FeCl₃-catalyzed intramolecular <i>N</i>-annulation.2024-01-01T00:00:00Z20242025-04-22T12:02:12.435Z2025-04-06T00:13:49.875ZS-EPMC112160823895296110.3762/bjoc.20.123