biostudies-literatureUnknown12Chen X<h4>Background</h4>Ovarian cancer is an aggressive malignancy with high mortality known for its considerable metastatic potential. This study aimed to explore the expression and functional role of Unc-51 like autophagy activating kinase 2 (ULK2) in the progression of ovarian cancer.<h4>Methods</h4>ULK2 expression patterns in ovarian cancer tissues as well as benign tumor control samples obtained from our institution were evaluated using immunohistochemistry. Cell counting kit 8 and Transwell assays were applied to assess the effects of ULK2 overexpression on cell proliferation, migration and invasion, respectively. RNA sequencing was performed to explore potential mechanisms of action of ULK2 beyond its classical autophagy modulation.<h4>Results</h4>Our experiments showed significant downrPeerJe17628https://www.ebi.ac.uk/biostudies/studies/S-EPMC11216209biostudies-literatureULK2 suppresses ovarian cancer cell migration and invasion by elevating IGFBP3.PMC11216209Liu JMa CYao BChen XZhu WSun HXu HShao CfalseULK2 suppresses ovarian cancer cell migration and invasion by elevating IGFBP3.<h4>Background</h4>Ovarian cancer is an aggressive malignancy with high mortality known for its considerable metastatic potential. This study aimed to explore the expression and functional role of Unc-51 like autophagy activating kinase 2 (ULK2) in the progression of ovarian cancer.<h4>Methods</h4>ULK2 expression patterns in ovarian cancer tissues as well as benign tumor control samples obtained from our institution were evaluated using immunohistochemistry. Cell counting kit 8 and Transwell assays were applied to assess the effects of ULK2 overexpression on cell proliferation, migration and invasion, respectively. RNA sequencing was performed to explore potential mechanisms of action of ULK2 beyond its classical autophagy modulation.<h4>Results</h4>Our experiments showed significant downr2024-01-01T00:00:00Z20242025-04-04T23:53:56.027Z2025-04-04T23:53:56.027ZS-EPMC112162093895298310.7717/peerj.17628