biostudies-literatureZeng Hthe First Affiliated Hospital of Yangtze UniversityHeath and Family Planning Commission of Hubei Provincethe Joint Fund project of Yangtze University221-230https://www.ebi.ac.uk/biostudies/studies/S-EPMC11216246biostudies-literatureUnknown18(6)<b>Objective:</b> This study intended to explore the relationship of PLK3 with prognosis in patients with colorectal cancer (CRC). <b>Methods:</b> PLK3 positivity was detected by immunohistochemistry in 160 patients with CRC receiving surgical resection. <b>Results:</b> The median tumor PLK3-positive rate was 26.5%. Tumor PLK3-positive rate was related to increased lymph node stage (p = 0.002) and tumor-node-metastasis stage (p < 0.001) of CRC. Tumor PLK3-positive rate ≥30% was related to shortened disease-free survival (p = 0.009) and overall survival (p = 0.003); tumor PLK3-positive rate ≥50% showed a stronger correlation with them (both p = 0.001), which was validated by multivariate Cox regression analyses (both p < 0.05). <b>Conclusion:</b> Tumor PLK3-positive rate ≥50% relates to incBiomarkers in medicinePLK3 is linked with higher tumor stage and unfavorable prognosis in patients with colorectal cancer.PMC11216246WJ2019-22WJ2018H2032022DIF01Zhang WYang YWang QLi SHe HXiang YZeng HTu XfalsePLK3 is linked with higher tumor stage and unfavorable prognosis in patients with colorectal cancer.<b>Objective:</b> This study intended to explore the relationship of PLK3 with prognosis in patients with colorectal cancer (CRC). <b>Methods:</b> PLK3 positivity was detected by immunohistochemistry in 160 patients with CRC receiving surgical resection. <b>Results:</b> The median tumor PLK3-positive rate was 26.5%. Tumor PLK3-positive rate was related to increased lymph node stage (p = 0.002) and tumor-node-metastasis stage (p < 0.001) of CRC. Tumor PLK3-positive rate ≥30% was related to shortened disease-free survival (p = 0.009) and overall survival (p = 0.003); tumor PLK3-positive rate ≥50% showed a stronger correlation with them (both p = 0.001), which was validated by multivariate Cox regression analyses (both p < 0.05). <b>Conclusion:</b> Tumor PLK3-positive rate ≥50% relates to inc2024-01-01T00:00:00Z20242025-06-26T03:06:26.64Z2025-06-26T03:06:26.64ZS-EPMC112162463862986210.2217/bmm-2023-0591