{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Estephan LE"],"pubmed_abstract":["<h4>Introduction</h4>Oral cavity squamous cell carcinoma (OSCC) occurs most frequently in patients >60 years old with a history of tobacco and alcohol use. Epidemiological studies describe increased incidence of OSCC in younger adults (<45 years). Despite its poor prognosis, knowledge of OSCC tumor microenvironment (TME) characteristics in younger adults is scarce and could help inform possible resistance to emerging treatment options.<h4>Methods</h4>Patients with OSCC were evaluated using TCGA-HNSC (n=121) and a stage and subsite-matched institutional cohort (n=8) to identify differential gene expression focusing on the extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) processes in younger (≤45 years) vs. older adults (≥60 years). NanoString nCounter analysis was perf"],"journal":["Frontiers in oncology"],"pagination":["1412212"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11217481"],"repository":["biostudies-literature"],"pubmed_title":["Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma."],"pmcid":["PMC11217481"],"pubmed_authors":["Johnson J","Curry JM","Estephan LE","Kumar G","Harshyne LA","Stewart M","Luginbuhl AJ","Martinez-Outschoorn UE","South AP","Mahoney MG","Banoub R","Linnenbach A"],"additional_accession":[]},"is_claimable":false,"name":"Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma.","description":"<h4>Introduction</h4>Oral cavity squamous cell carcinoma (OSCC) occurs most frequently in patients >60 years old with a history of tobacco and alcohol use. Epidemiological studies describe increased incidence of OSCC in younger adults (<45 years). Despite its poor prognosis, knowledge of OSCC tumor microenvironment (TME) characteristics in younger adults is scarce and could help inform possible resistance to emerging treatment options.<h4>Methods</h4>Patients with OSCC were evaluated using TCGA-HNSC (n=121) and a stage and subsite-matched institutional cohort (n=8) to identify differential gene expression focusing on the extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) processes in younger (≤45 years) vs. older adults (≥60 years). NanoString nCounter analysis was perf","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-21T16:14:20.719Z","creation":"2025-04-21T16:14:20.719Z"},"accession":"S-EPMC11217481","cross_references":{"pubmed":["38957320"],"doi":["10.3389/fonc.2024.1412212"]}}