{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(1)"],"submitter":["Vento G"],"funding":["Vygon Italia s.r.l.","Chiesi Foundation"],"pubmed_abstract":["<h4>Background</h4>Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). The goals of different methods of surfactant administration are to reduce the duration of mechanical ventilation and the severity of bronchopulmonary dysplasia (BPD); however, the optimal administration method remains unknown. This study compares the effectiveness of the INtubate-RECruit-SURfactant-Extubate (IN-REC-SUR-E) technique with the less-invasive surfactant administration (LISA) technique, in increasing BPD-free survival of preterm infants. This is an international unblinded multicenter randomized controlled study in which preterm infants will be randomized into two groups to receive IN-REC-SUR-E or LISA surfactant administration.<h4>Methods</h4>In this "],"journal":["Trials"],"pagination":["433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11218154"],"repository":["biostudies-literature"],"pubmed_title":["Comparison of \"IN-REC-SUR-E\" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial)."],"pmcid":["PMC11218154"],"pubmed_authors":["Corvaglia LT","Mattia L","Nider S","Schettini F","Motta M","Rinaldi M","Vento G","Galdo F","Ghirardello S","Nigro G","Distilo A","Conti R","Matina F","Corradi M","Ventura ML","Cools F","Montano S","Di Nicola P","Paolillo P","Gabriele A","Staffler A","Bresesti I","Leonardi V","Perotti G","Testa A","Marseglia L","Rigotti C","Carnielli VP","Manna A","Petrillo F","Barbini MC","Finer N","Mosca F","Paladini A","Luvara D","Guidotti I","Piga E","De Maio C","Martinelli S","Di Paolo A","Alighieri G","De Cosmo L","Borgarello G","Cavigioli F","Angileri V","Lio A","Patti L","Carbonara C","Giardina F","Martinelli D","Travan L","Morreale S","Perniola R","Tina G","Marcozzi P","Beghini R","Lanciotti L","Bottino R","Vitaliti G","La Torre G","Vitaliti M","Romano V","Gentile MP","Grison A","Pingitore GA","Primavera A","Ausanio G","Giuffre M","Li J","Marletta M","Roma E","Tirantello M","Villani PE","Dani C","Davis PG","Pittini C","Rosella V","Coscia A","Nuccio M","Mantelli SS","Fusco FP","Solinas A","Viola V","Viola S","Tomasini B","Maiolo K","Palatta S","Bracaglia G","Gizzi C","Minghetti D","Cacace C","Chierici V","Jian M","Pillow JJ","Leo F","Palamides S","Favini F","Pontiggia F","Borgione S","Maggio A","Grappone L","Wanker P","Barone C","Di Credico S","Borrelli A","Pasta E","Comito V","Lista G","Risso FM","Sorrentino E","Aversa S","Fracchiolla A","Maffei G","Nobile S","Maggio L","Ricotti A","Orfeo L","Bizzarri B","Rosati E","Castronovo A","Lucente M","Cecchi S","Betta P","Costa A","Cogo P","Corsello G","Lubrano R","Di Fabio S","D'Amico P","Pierro M","Consigli C","Aceti A","Balestri E","Napolitano M","Zanetta S","Gargano G","Lago P","Tuling G","Cimino C","Nicolardi A","Lavizzari A","Morselli I","Caravetta J","Proto A","Ozdemir SA","Pisu S","Termini D","Spaggiari E","Gitto E","Salvo V","Valenzano L","Guzzo I","Rapsomaniki M","Calzolari F","Cresi F","Fasolato VA","Liberatore P","Raimondi F","Herting E","Fattore S","Ottaviano C","Piccirillo A","Carta M","Sindico P","Pastorino R","Nardo D","Polglase G","Mores N","Pappalardo MG","Paviotti G","Bernardo I","Luciani S","Saporito A","Mescoli G","La Forgia N","Piazza MS","Fe C","Vedovato S","Greco I","La Placa S","Costa S","Grasso F","Cota F","Fatuzzo V","Pontrelli G","Capozza M","Malaigia L","Cavalleri E","Tirone C","Guglielmino R","Campagnoli MF","Giordano L","Morandi G","Sanfilippo C","Condo V","Nastro FF","Zannin E","Trevisanuto D","Mangili G","Cocca C","Sauna A","Cocca F","Stella M","Pasciuto T","Binotti M","Ferrari S","Paganin P","van Kaam AH","Terrin G","Ferrarello MP","Migliore IV","Perrone S","Romanini E","Yang Y","Tingay D","Ramenghi L","Vendramin S","Berardi A","Rulli I","Forcellini CA","Tormena F","Sepporta V","Tana M","Castoldi F","Crispino F","Agosti M","Perri A","Ancora G","Marciano A","Sannia A","Lestingi D","Del Campo G","Aurilia C","Lodin D","Falcone A","Gazzolo D","Di Valerio S","Quartulli L","Massenzi L","Picone S","Gallini F","Scorrano A","Capasso L","Capretti MG","Massari S","Cardilli V","Baraldi E","Duca V","Coma M","Gangemi A","Scapillati E","Falsaperla R","Tulino V","Maranella E","Burattini I","Mondello I","Bellan C"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of \"IN-REC-SUR-E\" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial).","description":"<h4>Background</h4>Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). The goals of different methods of surfactant administration are to reduce the duration of mechanical ventilation and the severity of bronchopulmonary dysplasia (BPD); however, the optimal administration method remains unknown. This study compares the effectiveness of the INtubate-RECruit-SURfactant-Extubate (IN-REC-SUR-E) technique with the less-invasive surfactant administration (LISA) technique, in increasing BPD-free survival of preterm infants. This is an international unblinded multicenter randomized controlled study in which preterm infants will be randomized into two groups to receive IN-REC-SUR-E or LISA surfactant administration.<h4>Methods</h4>In this ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T20:34:43.432Z","creation":"2025-04-06T11:38:26.443Z"},"accession":"S-EPMC11218154","cross_references":{"pubmed":["38956676"],"doi":["10.1186/s13063-024-08240-4"]}}