{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Neale ZE"],"funding":["BLRD VA","NIA NIH HHS","NIMH NIH HHS","NCI NIH HHS","National Institute of Mental Health","NIAMS NIH HHS","U.S. Department of Veterans Affairs","National Institute on Aging","CSRD VA"],"pagination":["143"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11218206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as risk for Alzheimer's disease and related dementias (ADRD). Overlapping symptom profiles observed in cognitive disorders, psychiatric disorders, and environmental exposures (e.g., head injury) can complicate the detection of early signs of ADRD. The interplay between PTSD, head injury, subjective (self-reported) cognitive concerns and genetic risk for ADRD is also not well understood, particularly in diverse ancestry groups.<h4>Methods</h4>Using data from the U.S. Department of Veterans Affairs (VA) Million Veteran Program (MVP), we examined the relationship between dementia risk factors (APOE ε4, PTSD, TBI) and subjective cognitive co"],"journal":["Alzheimer's research & therapy"],"pubmed_title":["Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans."],"pmcid":["PMC11218206"],"funding_grant_id":["I01 CX001727","T32MH019836","R01 AG050595","I01 BX005749","F32 CA090073","IK2CX002192-01A2","R33 CA094304","CX001727","R01 AR072703","BX004192","IK2 CX002192","T32 MH019836","AG050595","R01 CA094121","I01 BX004192"],"pubmed_authors":["Wilson P","Iruvanti P","Whitbourne SB","Zhang R","Gappy S","Jhala D","Gress TW","Argyres DP","Gutierrez S","Kinlay S","Liang P","Neale ZE","Aguayo S","Norton J","Poon S","Godschalk M","Palacio A","Tsao P","Moser J","DuVall SL","Dellitalia L","Brewer JV","Okusaga O","Xu J","Hauser E","Kranzler H","Churby L","Ahuja S","Shayan SA","Ballas Z","Moorman J","Potter E","Whooley M","Harley J","Liangpunsakul S","Lichy J","Williams AE","Luoh SW","Androulakis XM","Hammer K","Hauger RL","Deen JE","Kilbourne A","Tandon N","Servatius R","Miller MW","Gupta S","Faulk LC","Balasubramanian P","Klein J","Sriram P","Greco J","Murdoch M","Mahan CS","Cohen D","Panizzon MS","Matheny M","VA Million Veteran Program","Stephens B","Fonda JR","Beckham J","Wells J","Boyko E","Logue MW","Oslin D","Sherva R","Villareal G","Tsao PS","Sharma S","Mastorides S","Brophy MT","Wallbom A","Meyer P","Gesek F","Assimes TL","Jacono F","Hurley R","Fujii D","Landry M","Hung A","Whittle J","Mates E","Muralidhar S","Alexander K","Pyarajan S","Harrington KM","Cho K","Selva LE","Yeh SS","Wolf EJ","Fayad J","Hamner M","Merritt V","Walsh J","Strollo P","Rauchman M","Mattocks K","Oursler KA","Smith R","Morgan T","Bhushan S","Gaziano JM","Marrache R"],"additional_accession":[]},"is_claimable":false,"name":"Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans.","description":"<h4>Background</h4>Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as risk for Alzheimer's disease and related dementias (ADRD). Overlapping symptom profiles observed in cognitive disorders, psychiatric disorders, and environmental exposures (e.g., head injury) can complicate the detection of early signs of ADRD. The interplay between PTSD, head injury, subjective (self-reported) cognitive concerns and genetic risk for ADRD is also not well understood, particularly in diverse ancestry groups.<h4>Methods</h4>Using data from the U.S. Department of Veterans Affairs (VA) Million Veteran Program (MVP), we examined the relationship between dementia risk factors (APOE ε4, PTSD, TBI) and subjective cognitive co","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-05-29T17:52:06.293Z","creation":"2025-04-04T12:21:33.677Z"},"accession":"S-EPMC11218206","cross_references":{"pubmed":["38951900"],"doi":["10.1186/s13195-024-01512-w"]}}