{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Scott CJR"],"funding":["UKRI | Biotechnology and Biological Sciences Research Council","UKRI | Engineering and Physical Sciences Research Council (EPSRC)","European Research Council","UKRI | Engineering and Physical Sciences Research Council","Royal Society Ken Murray Research Professor","Biotechnology and Biological Sciences Research Council"],"pagination":["e0394323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11218486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(7)"],"pubmed_abstract":["<i>Parascedosporium putredinis</i> NO1 is a plant biomass-degrading ascomycete with a propensity to target the most recalcitrant components of lignocellulose. Here we applied proteomics and activity-based protein profiling (ABPP) to investigate the ability of <i>P. putredinis</i> NO1 to tailor its secretome for growth on different lignocellulosic substrates. Proteomic analysis of soluble and insoluble culture fractions following the growth of <i>P. putredinis</i> NO1 on six lignocellulosic substrates highlights the adaptability of the response of the <i>P. putredinis</i> NO1 secretome to different substrates. Differences in protein abundance profiles were maintained and observed across substrates after bioinformatic filtering of the data to remove intracellular protein contamination to ide"],"journal":["Microbiology spectrum"],"pubmed_title":["<i>Parascedosporium putredinis</i> NO1 tailors its secretome for different lignocellulosic substrates."],"pmcid":["PMC11218486"],"funding_grant_id":["BB/P027717/1","BB/W003309/1","ERC-2020-SyG-951231","EP/K039660/1, EP/M028127/1","BB/M011151/1","BB/W000695/1","951231","BB/P027717/1, BB/W000695/1, BB/W003309/1, BB/S01196X/1, BB/M011151/1"],"pubmed_authors":["McGregor NGS","Leadbeater DR","Setchfield A","Overkleeft HS","Bruce NC","Abood A","Scott CJR","Dowle A","Hoßbach J","Oates NC","Davies GJ"],"additional_accession":[]},"is_claimable":false,"name":"<i>Parascedosporium putredinis</i> NO1 tailors its secretome for different lignocellulosic substrates.","description":"<i>Parascedosporium putredinis</i> NO1 is a plant biomass-degrading ascomycete with a propensity to target the most recalcitrant components of lignocellulose. Here we applied proteomics and activity-based protein profiling (ABPP) to investigate the ability of <i>P. putredinis</i> NO1 to tailor its secretome for growth on different lignocellulosic substrates. Proteomic analysis of soluble and insoluble culture fractions following the growth of <i>P. putredinis</i> NO1 on six lignocellulosic substrates highlights the adaptability of the response of the <i>P. putredinis</i> NO1 secretome to different substrates. Differences in protein abundance profiles were maintained and observed across substrates after bioinformatic filtering of the data to remove intracellular protein contamination to ide","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T11:25:18.898Z","creation":"2025-04-04T11:25:18.898Z"},"accession":"S-EPMC11218486","cross_references":{"pubmed":["38757984"],"doi":["10.1128/spectrum.03943-23"]}}