{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tejeda-Garibay S"],"funding":["internal Lawrence National Livermore Directed Research and Development funds","NHLBI NIH HHS","Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research","ASUCM Academic Affairs Fellowships and Undergraduate Research Symposium (FURS)","The American Association of Immunologists Intersect Fellowship Program for Computational Scientists and Immunologists fellowship","University of California Office of the President Awards","ASUCM Academic Affairs Fellowships and Undergraduate Research Symposium"],"pagination":["e0297823"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11218535"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(7)"],"pubmed_abstract":["Coccidioidomycosis, also known as Valley fever, is a disease caused by the fungal pathogen <i>Coccidioides</i>. Unfortunately, patients are often misdiagnosed with bacterial pneumonia, leading to inappropriate antibiotic treatment. The soil <i>Bacillus subtilis</i>-like species exhibits antagonistic properties against <i>Coccidioides in vitro</i>; however, the antagonistic capabilities of host microbiota against <i>Coccidioides</i> are unexplored. We sought to examine the potential of the tracheal and intestinal microbiomes to inhibit the growth of <i>Coccidioides in vitro</i>. We hypothesized that an uninterrupted lawn of microbiota obtained from antibiotic-free mice would inhibit the growth of <i>Coccidioides,</i> while partial <i>in vitro</i> depletion through antibiotic disk diffusion "],"journal":["Microbiology spectrum"],"pubmed_title":["Host tracheal and intestinal microbiomes inhibit <i>Coccidioides</i> growth <i>in vitro</i>."],"pmcid":["PMC11218535"],"funding_grant_id":["F31 HL160203","MRP-17-454959, VFR-19-633952","22-ERD-010","F31HL160203"],"pubmed_authors":["Zhao L","Tejeda-Garibay S","Amiri B","Sindi SS","Weilhammer DR","Hoyer KK","Pimentel M","Hum NR","Loots GG","Diep AL"],"additional_accession":[]},"is_claimable":false,"name":"Host tracheal and intestinal microbiomes inhibit <i>Coccidioides</i> growth <i>in vitro</i>.","description":"Coccidioidomycosis, also known as Valley fever, is a disease caused by the fungal pathogen <i>Coccidioides</i>. Unfortunately, patients are often misdiagnosed with bacterial pneumonia, leading to inappropriate antibiotic treatment. The soil <i>Bacillus subtilis</i>-like species exhibits antagonistic properties against <i>Coccidioides in vitro</i>; however, the antagonistic capabilities of host microbiota against <i>Coccidioides</i> are unexplored. We sought to examine the potential of the tracheal and intestinal microbiomes to inhibit the growth of <i>Coccidioides in vitro</i>. We hypothesized that an uninterrupted lawn of microbiota obtained from antibiotic-free mice would inhibit the growth of <i>Coccidioides,</i> while partial <i>in vitro</i> depletion through antibiotic disk diffusion ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-29T12:10:09.091Z","creation":"2024-11-09T15:16:46.837Z"},"accession":"S-EPMC11218535","cross_references":{"pubmed":["38832766"],"doi":["10.1128/spectrum.02978-23"]}}