{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["El Jamal C"],"funding":["NCATS NIH HHS","NIA NIH HHS","NIDA NIH HHS","FIC NIH HHS","NIEHS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIAAA NIH HHS","NCCIH NIH HHS","NIDDK NIH HHS","RRD VA","NINR NIH HHS","NINDS NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["1328-1335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11218548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(5)"],"pubmed_abstract":["<h4>Background</h4>Few studies have investigated tolerability, blinding, and double-blinding of High-Definition transcranial Direct Current Stimulation (HD-tDCS) at amplitudes above 2 milliamps (mA).<h4>Objective</h4>We examined a) tolerability of HD-tDCS during stimulation sessions and b) blinding and double blinding of participants and study team members.<h4>Methods</h4>Data from a mixed neurologic sample of 292 older adults were pooled from 3046 HD-tDCS sessions (2329 active; 717 sham). Per electrode amplitudes ranged from 1 mA to 4 mA with total currents up to 10 mA. Participants completed a standardized sensation (tolerability) questionnaire after each session. Participants and study team members stated whether the participant received active or sham stimulation at the end of various "],"journal":["Brain stimulation"],"pubmed_title":["Tolerability and blinding of high-definition transcranial direct current stimulation among older adults at intensities of up to 4 mA per electrode."],"pmcid":["PMC11218548"],"funding_grant_id":["R01 AG058724","P30 AG053760","D43 TW009883","R01 AT006978","T32 GM136499","R01 CA102667","UL1 TR001427","R01 NS101362","R35 AG072262","R01 AT010060","R01 NS094413","R21 DK063179","P01 HL039707","T34 GM137858","P01 HL087226","R01 AA016151","UG3 DA048502","R01 AI098511","P30 ES010126","I01 RX001534","P30 AG024832","R01 NR016093","K08 AI051565","P30 AG066511","T32 NR016914","R01 NS112996"],"pubmed_authors":["Bikson M","Iordan AD","Rahman-Filipiak A","Harrie A","DaSilva AF","El Jamal C","Hampstead BM","Vesia M","Ploutz-Snyder R","Khadr L"],"additional_accession":[]},"is_claimable":false,"name":"Tolerability and blinding of high-definition transcranial direct current stimulation among older adults at intensities of up to 4 mA per electrode.","description":"<h4>Background</h4>Few studies have investigated tolerability, blinding, and double-blinding of High-Definition transcranial Direct Current Stimulation (HD-tDCS) at amplitudes above 2 milliamps (mA).<h4>Objective</h4>We examined a) tolerability of HD-tDCS during stimulation sessions and b) blinding and double blinding of participants and study team members.<h4>Methods</h4>Data from a mixed neurologic sample of 292 older adults were pooled from 3046 HD-tDCS sessions (2329 active; 717 sham). Per electrode amplitudes ranged from 1 mA to 4 mA with total currents up to 10 mA. Participants completed a standardized sensation (tolerability) questionnaire after each session. Participants and study team members stated whether the participant received active or sham stimulation at the end of various ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep-Oct","modification":"2026-04-30T21:28:05.94Z","creation":"2025-04-04T12:22:08.129Z"},"accession":"S-EPMC11218548","cross_references":{"pubmed":["37660936"],"doi":["10.1016/j.brs.2023.08.025"]}}