biostudies-literatureEl Jamal CNCATS NIH HHSNIA NIH HHSNIDA NIH HHSFIC NIH HHSNIEHS NIH HHSNIAID NIH HHSNHLBI NIH HHSNIAAA NIH HHSNCCIH NIH HHSNIDDK NIH HHSRRD VANINR NIH HHSNINDS NIH HHSNCI NIH HHSNIGMS NIH HHS1328-1335https://www.ebi.ac.uk/biostudies/studies/S-EPMC11218548biostudies-literatureUnknown16(5)<h4>Background</h4>Few studies have investigated tolerability, blinding, and double-blinding of High-Definition transcranial Direct Current Stimulation (HD-tDCS) at amplitudes above 2 milliamps (mA).<h4>Objective</h4>We examined a) tolerability of HD-tDCS during stimulation sessions and b) blinding and double blinding of participants and study team members.<h4>Methods</h4>Data from a mixed neurologic sample of 292 older adults were pooled from 3046 HD-tDCS sessions (2329 active; 717 sham). Per electrode amplitudes ranged from 1 mA to 4 mA with total currents up to 10 mA. Participants completed a standardized sensation (tolerability) questionnaire after each session. Participants and study team members stated whether the participant received active or sham stimulation at the end of various Brain stimulationTolerability and blinding of high-definition transcranial direct current stimulation among older adults at intensities of up to 4 mA per electrode.PMC11218548R01 AG058724P30 AG053760D43 TW009883R01 AT006978T32 GM136499R01 CA102667UL1 TR001427R01 NS101362R35 AG072262R01 AT010060R01 NS094413R21 DK063179P01 HL039707T34 GM137858P01 HL087226R01 AA016151UG3 DA048502R01 AI098511P30 ES010126I01 RX001534P30 AG024832R01 NR016093K08 AI051565P30 AG066511T32 NR016914R01 NS112996Bikson MIordan ADRahman-Filipiak AHarrie ADaSilva AFEl Jamal CHampstead BMVesia MPloutz-Snyder RKhadr LfalseTolerability and blinding of high-definition transcranial direct current stimulation among older adults at intensities of up to 4 mA per electrode.<h4>Background</h4>Few studies have investigated tolerability, blinding, and double-blinding of High-Definition transcranial Direct Current Stimulation (HD-tDCS) at amplitudes above 2 milliamps (mA).<h4>Objective</h4>We examined a) tolerability of HD-tDCS during stimulation sessions and b) blinding and double blinding of participants and study team members.<h4>Methods</h4>Data from a mixed neurologic sample of 292 older adults were pooled from 3046 HD-tDCS sessions (2329 active; 717 sham). Per electrode amplitudes ranged from 1 mA to 4 mA with total currents up to 10 mA. Participants completed a standardized sensation (tolerability) questionnaire after each session. Participants and study team members stated whether the participant received active or sham stimulation at the end of various 2023-01-01T00:00:00Z2023 Sep-Oct2026-04-30T21:28:05.94Z2025-04-04T12:22:08.129ZS-EPMC112185483766093610.1016/j.brs.2023.08.025