{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(11)"],"submitter":["Wang L"],"pubmed_abstract":["An efficient method was discovered for catalyzing the esterification under air using Novozym 435 to obtain pyridine esters. The following conditions were found to be optimal: 60 mg of Novozyme 435, 5.0 mL of n-hexane, a molar ratio of 2:1 for nicotinic acids (0.4 mmol) to alcohols (0.2 mmol), 0.25 g of molecular sieve 3A, a revolution speed of 150 rpm, a reaction temperature of 50 °C, and reaction time of 48 h. Under nine cycles of Novozym 435, the 80 % yield was consistently obtained. Optimum conditions were used to synthesize 23 pyridine esters, including five novel compounds. Among them, gas chromatography-mass spectrometry-olfactometry (GC-MS-O) showed phenethyl nicotinate (<b>3g</b>), (<i>E</i>)-hex-4-en-1-yl nicotinate (<b>3m</b>), and octyl nicotinate (<b>3n</b>) possessed strong ar"],"journal":["Heliyon"],"pagination":["e32435"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11219360"],"repository":["biostudies-literature"],"pubmed_title":["Enzymatic synthesis of pyridine heterocyclic compounds and their thermal stability."],"pmcid":["PMC11219360"],"pubmed_authors":["Zhou M","Wu Z","Zhao M","Wang P","Zhao Q","Wu G","Lai M","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Enzymatic synthesis of pyridine heterocyclic compounds and their thermal stability.","description":"An efficient method was discovered for catalyzing the esterification under air using Novozym 435 to obtain pyridine esters. The following conditions were found to be optimal: 60 mg of Novozyme 435, 5.0 mL of n-hexane, a molar ratio of 2:1 for nicotinic acids (0.4 mmol) to alcohols (0.2 mmol), 0.25 g of molecular sieve 3A, a revolution speed of 150 rpm, a reaction temperature of 50 °C, and reaction time of 48 h. Under nine cycles of Novozym 435, the 80 % yield was consistently obtained. Optimum conditions were used to synthesize 23 pyridine esters, including five novel compounds. Among them, gas chromatography-mass spectrometry-olfactometry (GC-MS-O) showed phenethyl nicotinate (<b>3g</b>), (<i>E</i>)-hex-4-en-1-yl nicotinate (<b>3m</b>), and octyl nicotinate (<b>3n</b>) possessed strong ar","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-18T13:51:26.817Z","creation":"2025-04-04T12:54:42.107Z"},"accession":"S-EPMC11219360","cross_references":{"pubmed":["38961989"],"doi":["10.1016/j.heliyon.2024.e32435"]}}