biostudies-literatureHe DNational Key R&amp;D Program of ChinaProgram of Guangdong Provincial Clinical Research Center for Digestive DiseasesComplete Period Talent Project of the Sixth Affiliated HospitalNational Key R&D Program of ChinaNational Key Clinical DisciplineNational Natural Science Foundation of ChinaNatural Science Foundation of Guangdong ProvinceGuangdong Special Young Talent Plan of Scientific and Technological Innovation3783-3798https://www.ebi.ac.uk/biostudies/studies/S-EPMC11219408biostudies-literatureUnknown38(7)<h4>Background</h4>Many studies reported the presence of adenomas with high-grade dysplasia (HGD) at index colonoscopy increased the incidence of advanced neoplasia (AN) and colorectal cancer (CRC) following. However, the conclusion remains obscure due to lack of studies on the specific population of adenomas with HGD. This study aimed to assess the long-term risk of AN and CRC after removal of adenomas with HGD.<h4>Methods</h4>A total of 814 patients who underwent adenomas with HGD removal between 2010 and 2019 were retrospectively analyzed. The outcomes were the incidences of AN and CRC during surveillance colonoscopy. Cox proportional hazards models were utilized to identify risk factors associated with AN and CRC.<h4>Results</h4>During more than 2000 person-years of follow-up, we foundSurgical endoscopyRisk of advanced neoplasia after removal of colorectal adenomas with high-grade dysplasia.PMC11219408819704822022B1515020022R202102172025019762020B1111170004821725612019A15150113132023YFC2507401Li GHe DChen JHu JZhang YJiang XHe XChen HLiu DWang KfalseRisk of advanced neoplasia after removal of colorectal adenomas with high-grade dysplasia.<h4>Background</h4>Many studies reported the presence of adenomas with high-grade dysplasia (HGD) at index colonoscopy increased the incidence of advanced neoplasia (AN) and colorectal cancer (CRC) following. However, the conclusion remains obscure due to lack of studies on the specific population of adenomas with HGD. This study aimed to assess the long-term risk of AN and CRC after removal of adenomas with HGD.<h4>Methods</h4>A total of 814 patients who underwent adenomas with HGD removal between 2010 and 2019 were retrospectively analyzed. The outcomes were the incidences of AN and CRC during surveillance colonoscopy. Cox proportional hazards models were utilized to identify risk factors associated with AN and CRC.<h4>Results</h4>During more than 2000 person-years of follow-up, we found2024-01-01T00:00:00Z2024 Jul2025-04-04T12:54:48.082Z2025-04-04T12:54:48.082ZS-EPMC112194083880695510.1007/s00464-024-10898-5