{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mao M"],"funding":["Karolinska Institutet, Stockholm, Sweden","the National Key R&D Program of China Ministry of Sciences and Technology","the Natural Science Foundation of Shandong Province","the Swedish Foundation for International Cooperation in Research and Higher Education","the Alzheimer’s Association Grant","the Swedish Research Council","the Brain Science and Brain-like Intelligence Technology Research Projects of China","the Alzheimer's Association Grant","the National Natural Science Foundation of China","Karolinska Institute"],"pagination":["15162"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11219852"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Prolonged ventricular repolarization has been associated with cardiovascular disease. We sought to investigate the association of prolonged ventricular repolarization with mild cognitive impairment (MCI) and the potential underlying neuropathological mechanisms in older adults. This cross-sectional study included 4328 dementia-free participants (age ≥ 65 years; 56.8% female) in the baseline examination of the Multidomain INterventions to delay dementia and Disability in rural China; of these, 989 undertook structural brain magnetic resonance imaging (MRI) scans. QT, QTc, JT, JTc, and QRS intervals were derived from 12-lead electrocardiograph. MCI, amnestic MCI (aMCI), and non-amnestic MCI (naMCI) were defined following the Petersen's criteria. Volumes of gray matter (GM), white matter, cer"],"journal":["Scientific reports"],"pubmed_title":["Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study."],"pmcid":["PMC11219852"],"funding_grant_id":["2021ZD0201808","AACSFD-22-922844","ZR2021MH005","2017-05819","2020-01574","2021ZD0201801","CH2019-8320","81861138008","2017YFC1310100"],"pubmed_authors":["Song L","Mao M","Dong Y","Cong L","Wang C","Qiu C","Han X","Liu R","Du Y","Wang Y","Wei Y"],"additional_accession":[]},"is_claimable":false,"name":"Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study.","description":"Prolonged ventricular repolarization has been associated with cardiovascular disease. We sought to investigate the association of prolonged ventricular repolarization with mild cognitive impairment (MCI) and the potential underlying neuropathological mechanisms in older adults. This cross-sectional study included 4328 dementia-free participants (age ≥ 65 years; 56.8% female) in the baseline examination of the Multidomain INterventions to delay dementia and Disability in rural China; of these, 989 undertook structural brain magnetic resonance imaging (MRI) scans. QT, QTc, JT, JTc, and QRS intervals were derived from 12-lead electrocardiograph. MCI, amnestic MCI (aMCI), and non-amnestic MCI (naMCI) were defined following the Petersen's criteria. Volumes of gray matter (GM), white matter, cer","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T19:23:13.395Z","creation":"2025-04-04T19:23:13.395Z"},"accession":"S-EPMC11219852","cross_references":{"pubmed":["38956440"],"doi":["10.1038/s41598-024-65364-y"]}}