biostudies-literatureUnknown32(7)Hammer-Hansen SBørnecancerfondenThe European Union’s Interregional Øresund–Kattegat–Skagerrak grantKræftens BekæmpelseThe care for patients with serious conditions is increasingly guided by genomic medicine, and genomic medicine may equally transform care for healthy individual if genomic population screening is implemented. This study examines the medical impact of opportunistic genomic screening (OGS) in a cohort of patients undergoing comprehensive genomic germline DNA testing for childhood cancer, including the impact on their relatives. Medical actionability and uptake after cascade testing in the period following disclosure of OGS results was quantified. A secondary finding was reported to 19/595 (3.2%) probands primarily in genes related to cardiovascular and lipid disorders. After a mean follow up time of 1.6 years (Interquartile range (IQR): 0.57-1.92 yrs.) only 12 (63%) of these variants were foEuropean journal of human genetics : EJHG846-857https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220050biostudies-literatureActionability and familial uptake following opportunistic genomic screening in a pediatric cancer cohort.PMC11220050Bundgaard HBartels EJuul KStoltze USchmiegelow KHammer-Hansen SByrjalsen ATybjærg-Hansen ADiness BRTfelt JWadt KHansen TVOfalseActionability and familial uptake following opportunistic genomic screening in a pediatric cancer cohort.The care for patients with serious conditions is increasingly guided by genomic medicine, and genomic medicine may equally transform care for healthy individual if genomic population screening is implemented. This study examines the medical impact of opportunistic genomic screening (OGS) in a cohort of patients undergoing comprehensive genomic germline DNA testing for childhood cancer, including the impact on their relatives. Medical actionability and uptake after cascade testing in the period following disclosure of OGS results was quantified. A secondary finding was reported to 19/595 (3.2%) probands primarily in genes related to cardiovascular and lipid disorders. After a mean follow up time of 1.6 years (Interquartile range (IQR): 0.57-1.92 yrs.) only 12 (63%) of these variants were fo2024-01-01T00:00:00Z2024 Jul2026-07-15T08:23:17.137Z2025-04-04T12:21:31.876ZS-EPMC112200503874089710.1038/s41431-024-01618-7