{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duong HA"],"funding":["NEI NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)","NCRR NIH HHS","NIMHD NIH HHS","NIGMS NIH HHS"],"pagination":["5537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220080"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Circadian gene expression is fundamental to the establishment and functions of the circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is affected by environmental-circadian disruption (ECD) such as shiftwork and jetlag are ill-defined. Here, we provided a comprehensive and comparative description of male liver circadian gene expression, encompassing transcriptomes, whole-cell proteomes and nuclear proteomes, under normal and after ECD conditions. Under both conditions, post-translation, rather than transcription, is the dominant contributor to circadian functional outputs. After ECD, post-transcriptional and post-translational processes are the major contributors to whole-cell or nuclear circadian proteome, respectively. Furthermore, ECD re-writes the "],"journal":["Nature communications"],"pubmed_title":["Environmental circadian disruption re-writes liver circadian proteomes."],"pmcid":["PMC11220080"],"funding_grant_id":["SC1 GM127260","1R16GM146703-01","U54 MD007602","G12 RR003034","R21 EY031821","R01 EY026291","R16 GM146703","SC1 GM135112","R35 GM136661","R35 GM127044"],"pubmed_authors":["Duong HA","Ehlen C","DeBruyne JP","Baba K","Tosini G","Davidson AJ","Powell M"],"additional_accession":[]},"is_claimable":false,"name":"Environmental circadian disruption re-writes liver circadian proteomes.","description":"Circadian gene expression is fundamental to the establishment and functions of the circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is affected by environmental-circadian disruption (ECD) such as shiftwork and jetlag are ill-defined. Here, we provided a comprehensive and comparative description of male liver circadian gene expression, encompassing transcriptomes, whole-cell proteomes and nuclear proteomes, under normal and after ECD conditions. Under both conditions, post-translation, rather than transcription, is the dominant contributor to circadian functional outputs. After ECD, post-transcriptional and post-translational processes are the major contributors to whole-cell or nuclear circadian proteome, respectively. Furthermore, ECD re-writes the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-29T11:20:27.888Z","creation":"2025-04-04T12:54:18.317Z"},"accession":"S-EPMC11220080","cross_references":{"pubmed":["38956413"],"doi":["10.1038/s41467-024-49852-3"]}}