biostudies-literatureDuong HANEI NIH HHSU.S. Department of Health & Human Services | NIH | National Institute of General Medical SciencesU.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)NCRR NIH HHSNIMHD NIH HHSNIGMS NIH HHS5537https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220080biostudies-literatureUnknown15(1)Circadian gene expression is fundamental to the establishment and functions of the circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is affected by environmental-circadian disruption (ECD) such as shiftwork and jetlag are ill-defined. Here, we provided a comprehensive and comparative description of male liver circadian gene expression, encompassing transcriptomes, whole-cell proteomes and nuclear proteomes, under normal and after ECD conditions. Under both conditions, post-translation, rather than transcription, is the dominant contributor to circadian functional outputs. After ECD, post-transcriptional and post-translational processes are the major contributors to whole-cell or nuclear circadian proteome, respectively. Furthermore, ECD re-writes the Nature communicationsEnvironmental circadian disruption re-writes liver circadian proteomes.PMC11220080SC1 GM1272601R16GM146703-01U54 MD007602G12 RR003034R21 EY031821R01 EY026291R16 GM146703SC1 GM135112R35 GM136661R35 GM127044Duong HAEhlen CDeBruyne JPBaba KTosini GDavidson AJPowell MfalseEnvironmental circadian disruption re-writes liver circadian proteomes.Circadian gene expression is fundamental to the establishment and functions of the circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is affected by environmental-circadian disruption (ECD) such as shiftwork and jetlag are ill-defined. Here, we provided a comprehensive and comparative description of male liver circadian gene expression, encompassing transcriptomes, whole-cell proteomes and nuclear proteomes, under normal and after ECD conditions. Under both conditions, post-translation, rather than transcription, is the dominant contributor to circadian functional outputs. After ECD, post-transcriptional and post-translational processes are the major contributors to whole-cell or nuclear circadian proteome, respectively. Furthermore, ECD re-writes the 2024-01-01T00:00:00Z2024 Jul2026-05-29T11:20:27.888Z2025-04-04T12:54:18.317ZS-EPMC112200803895641310.1038/s41467-024-49852-3