biostudies-literatureTeboul LAgence Nationale de la RechercheAgence Nationale de la Recherche (French National Research Agency)NIH HHS5574https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220107biostudies-literatureUnknown15(1)The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals' genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.Nature communicationsImproving laboratory animal genetic reporting: LAG-R guidelines.PMC11220107ANR-10-INBS-07U42 OD010921Bunton-Stasyshyn RDobbie MPardo Manuel de Villena FWells SWang CKWarming SHeaney JPavlovic GMann GJHaffner RArkell RMSeong JKAsian Mouse Mutagenesis Resource AssociationAmos-Landgraf JMutant Mouse Resource and Research CentersFuchtbauer EMGolzio CMarvel JKueh AJFranklin CLInternational Society for Transgenic TechnologiesPhenomics AustraliaMagnuson TRLutz CCPailhoux EPeterson KWhitelaw CBMurray SAInternational Mouse Phenotyping ConsortiumThomas PQCELPHEDIA infrastructureGao XLloyd KCKRRRC- Rat Resource and Research CenterChin HJCrispo MBryda EKorf IFMontoliu LVilotte JLHrabe de Angelis MNam KHBirling MCSmith CTeboul LReinholdt LShiroishi TTinsley LHerault YNutter LMJINFRAFRONTIER consortiumDelerue FYoshiki AInternational Mammalian Genome SocietyTakeo TSedlacek RBenavides FJBrown SDMZarubica AfalseImproving laboratory animal genetic reporting: LAG-R guidelines.The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals' genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.2024-01-01T00:00:00Z2024 Jul2025-04-22T12:03:29.372Z2025-04-06T00:14:18.96ZS-EPMC112201073895643010.1038/s41467-024-49439-y