{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(26)"],"submitter":["Monta-Gonzalez G"],"pubmed_abstract":["Molecular cages are three-dimensional supramolecular structures that completely wrap guest molecules by encapsulation. We describe a rare comparative study between a metallo-organic cage and a fully organic analogous system, obtained by hydrazone bond formation self-assembly. Both cages are able to encapsulate the anticancer drug doxorubicin, with the organic cage forming a 1 : 1 inclusion complex with μM affinity, whereas the metallo-organic host experiences disassembly by interaction with the drug. Stability experiments reveal that the ligands of the metallo-organic cage are displaced in buffer at neutral, acidic, and basic pH, while the organic cage only disassembles under acidic conditions. Notably, the organic cage also shows minimal cell toxicity, even at high doses, whilst the doxor"],"journal":["Chemical science"],"pagination":["10010-10017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220577"],"repository":["biostudies-literature"],"pubmed_title":["Comparing organic and metallo-organic hydrazone molecular cages as potential carriers for doxorubicin delivery."],"pmcid":["PMC11220577"],"pubmed_authors":["Garcia-Fernandez A","Monta-Gonzalez G","Martinez-Manez R","Lusby PJ","Marti-Centelles V","Bastante-Rodriguez D"],"additional_accession":[]},"is_claimable":false,"name":"Comparing organic and metallo-organic hydrazone molecular cages as potential carriers for doxorubicin delivery.","description":"Molecular cages are three-dimensional supramolecular structures that completely wrap guest molecules by encapsulation. We describe a rare comparative study between a metallo-organic cage and a fully organic analogous system, obtained by hydrazone bond formation self-assembly. Both cages are able to encapsulate the anticancer drug doxorubicin, with the organic cage forming a 1 : 1 inclusion complex with μM affinity, whereas the metallo-organic host experiences disassembly by interaction with the drug. Stability experiments reveal that the ligands of the metallo-organic cage are displaced in buffer at neutral, acidic, and basic pH, while the organic cage only disassembles under acidic conditions. Notably, the organic cage also shows minimal cell toxicity, even at high doses, whilst the doxor","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-04T19:23:25.56Z","creation":"2025-04-04T19:23:25.56Z"},"accession":"S-EPMC11220577","cross_references":{"pubmed":["38966373"],"doi":["10.1039/d4sc02294g"]}}