{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(4)"],"submitter":["Saravolatz LD"],"funding":["Thomas Mackey Center for Infectious Disease Research","Ascension St John Hospital Department of Medicine"],"pubmed_abstract":["<h4>Background</h4>Rhodomyrtone is a novel plant-derived antibiotic compound originally isolated from <i>Rhodomyrtus tomentosa</i> leaf extract.<h4>Objectives</h4>To evaluate the activity of rhodomyrtone against a group of MRSA strains, including isolates with reduced susceptibility or resistance to vancomycin, daptomycin, linezolid and ceftaroline.<h4>Methods</h4>Broth microdilution testing was used to determine the MICs and MBCs of rhodomyrtone, fosfomycin, vancomycin, daptomycin, linezolid and ceftaroline.<h4>Results</h4>ROM had an MIC<sub>90</sub> of 1 mg/L against 110 strains of MRSA from blood isolates as well as for all other isolates that were daptomycin resistant, VISA, VRSA or LRSA. The MBC<sub>90</sub> were 4 mg/L across all groups tested. Among all <i>S. aureus</i> groups teste"],"journal":["JAC-antimicrobial resistance"],"pagination":["dlae097"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220652"],"repository":["biostudies-literature"],"pubmed_title":["Rhodomyrtone: a new anti-<i>Staphylococcus aureus</i> agent against resistant strains."],"pmcid":["PMC11220652"],"pubmed_authors":["Pawlak J","Saravolatz LD"],"additional_accession":[]},"is_claimable":false,"name":"Rhodomyrtone: a new anti-<i>Staphylococcus aureus</i> agent against resistant strains.","description":"<h4>Background</h4>Rhodomyrtone is a novel plant-derived antibiotic compound originally isolated from <i>Rhodomyrtus tomentosa</i> leaf extract.<h4>Objectives</h4>To evaluate the activity of rhodomyrtone against a group of MRSA strains, including isolates with reduced susceptibility or resistance to vancomycin, daptomycin, linezolid and ceftaroline.<h4>Methods</h4>Broth microdilution testing was used to determine the MICs and MBCs of rhodomyrtone, fosfomycin, vancomycin, daptomycin, linezolid and ceftaroline.<h4>Results</h4>ROM had an MIC<sub>90</sub> of 1 mg/L against 110 strains of MRSA from blood isolates as well as for all other isolates that were daptomycin resistant, VISA, VRSA or LRSA. The MBC<sub>90</sub> were 4 mg/L across all groups tested. Among all <i>S. aureus</i> groups teste","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-01T20:34:55.196Z","creation":"2025-04-06T00:12:32.589Z"},"accession":"S-EPMC11220652","cross_references":{"pubmed":["38966334"],"doi":["10.1093/jacamr/dlae097"]}}