biostudies-literatureUnknown6(4)Saravolatz LDThomas Mackey Center for Infectious Disease ResearchAscension St John Hospital Department of Medicine<h4>Background</h4>Rhodomyrtone is a novel plant-derived antibiotic compound originally isolated from <i>Rhodomyrtus tomentosa</i> leaf extract.<h4>Objectives</h4>To evaluate the activity of rhodomyrtone against a group of MRSA strains, including isolates with reduced susceptibility or resistance to vancomycin, daptomycin, linezolid and ceftaroline.<h4>Methods</h4>Broth microdilution testing was used to determine the MICs and MBCs of rhodomyrtone, fosfomycin, vancomycin, daptomycin, linezolid and ceftaroline.<h4>Results</h4>ROM had an MIC₉₀ of 1 mg/L against 110 strains of MRSA from blood isolates as well as for all other isolates that were daptomycin resistant, VISA, VRSA or LRSA. The MBC₉₀ were 4 mg/L across all groups tested. Among all <i>S. aureus</i> groups testeJAC-antimicrobial resistancedlae097https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220652biostudies-literatureRhodomyrtone: a new anti-<i>Staphylococcus aureus</i> agent against resistant strains.PMC11220652Pawlak JSaravolatz LDfalseRhodomyrtone: a new anti-<i>Staphylococcus aureus</i> agent against resistant strains.<h4>Background</h4>Rhodomyrtone is a novel plant-derived antibiotic compound originally isolated from <i>Rhodomyrtus tomentosa</i> leaf extract.<h4>Objectives</h4>To evaluate the activity of rhodomyrtone against a group of MRSA strains, including isolates with reduced susceptibility or resistance to vancomycin, daptomycin, linezolid and ceftaroline.<h4>Methods</h4>Broth microdilution testing was used to determine the MICs and MBCs of rhodomyrtone, fosfomycin, vancomycin, daptomycin, linezolid and ceftaroline.<h4>Results</h4>ROM had an MIC₉₀ of 1 mg/L against 110 strains of MRSA from blood isolates as well as for all other isolates that were daptomycin resistant, VISA, VRSA or LRSA. The MBC₉₀ were 4 mg/L across all groups tested. Among all <i>S. aureus</i> groups teste2024-01-01T00:00:00Z2024 Aug2026-06-01T20:34:55.196Z2025-04-06T00:12:32.589ZS-EPMC112206523896633410.1093/jacamr/dlae097