biostudies-literatureUnknown24(1)Fang Y<h4>Background</h4>Women at middle age are puzzled by a series of menopausal disturbances, can be distressing and considerably affect the personal, social and work lives. We aim to estimate the global prevalence of nineteen menopausal symptoms among middle-aged women by performing a systematic review and meta-analysis.<h4>Methods</h4>Comprehensive search was performed in multiple databases from January, 2000 to March, 2023 for relevant studies. Random-effect model with double-arcsine transformation was used for data analysis.<h4>Results</h4>A total of 321 studies comprised of 482,067 middle-aged women were included for further analysis. We found varied prevalence of menopausal symptoms, with the highest prevalence of joint and muscular discomfort (65.43%, 95% CI 62.51-68.29) and lowest of BMC public health1767https://www.ebi.ac.uk/biostudies/studies/S-EPMC11220992biostudies-literatureMapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis.PMC11220992Fang YLiu YLiu JZheng XLi ZYang LZhang XChen LLi KLiu FfalseMapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis.<h4>Background</h4>Women at middle age are puzzled by a series of menopausal disturbances, can be distressing and considerably affect the personal, social and work lives. We aim to estimate the global prevalence of nineteen menopausal symptoms among middle-aged women by performing a systematic review and meta-analysis.<h4>Methods</h4>Comprehensive search was performed in multiple databases from January, 2000 to March, 2023 for relevant studies. Random-effect model with double-arcsine transformation was used for data analysis.<h4>Results</h4>A total of 321 studies comprised of 482,067 middle-aged women were included for further analysis. We found varied prevalence of menopausal symptoms, with the highest prevalence of joint and muscular discomfort (65.43%, 95% CI 62.51-68.29) and lowest of 2024-01-01T00:00:00Z2024 Jul2026-05-07T14:19:02.495Z2025-04-06T00:11:59.191ZS-EPMC112209923895648010.1186/s12889-024-19280-5