biostudies-literatureJiang JNational Natural Science Foundation of ChinaNational Key Research and Development Program of China149https://www.ebi.ac.uk/biostudies/studies/S-EPMC11221040biostudies-literatureUnknown16(1)<h4>Background</h4>Enlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer's disease (AD) and inversely correlated with cognitive performance. However, its clinical diagnostic and predictive value, and mechanisms by which ChP impacts the AD continuum remain unclear.<h4>Methods</h4>This prospective cohort study enrolled 607 participants [healthy control (HC): 110, mild cognitive impairment (MCI): 269, AD dementia: 228] from the Chinese Imaging, Biomarkers, and Lifestyle study between January 1, 2021, and December 31, 2022. Of the 497 patients on the AD continuum, 138 underwent lumbar puncture for cerebrospinal fluid (CSF) hallmark testing. The relationships between ChP volume and CSF pathological hallmarks (Aβ₄₂, Aβ₄₀, Aβ_42/40, tTauAlzheimer's research & therapyChoroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer's continuum.PMC112210402021YFC2500100 and 2021YFC250010382071187 and 81870821Jiang JWang AZhuo ZJiang SXu JWang LLi WLiu YZhao MAwan MUNYang SDuan YRen QfalseChoroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer's continuum.<h4>Background</h4>Enlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer's disease (AD) and inversely correlated with cognitive performance. However, its clinical diagnostic and predictive value, and mechanisms by which ChP impacts the AD continuum remain unclear.<h4>Methods</h4>This prospective cohort study enrolled 607 participants [healthy control (HC): 110, mild cognitive impairment (MCI): 269, AD dementia: 228] from the Chinese Imaging, Biomarkers, and Lifestyle study between January 1, 2021, and December 31, 2022. Of the 497 patients on the AD continuum, 138 underwent lumbar puncture for cerebrospinal fluid (CSF) hallmark testing. The relationships between ChP volume and CSF pathological hallmarks (Aβ₄₂, Aβ₄₀, Aβ_42/40, tTau2024-01-01T00:00:00Z2024 Jul2025-04-04T19:24:11.6Z2025-04-04T19:24:11.6ZS-EPMC112210403896140610.1186/s13195-024-01520-w